Expression pattern of NOGO-A protein in the human nervous system

The distribution pattern of NOGO-A protein, an important axon growth inhibitory molecule and member of the reticulon family, has been investigated in the adult human brain, spinal cord, retina and dorsal root ganglia. Intense NOGO-A immunoreactivity was detected in oligodendroglial cell bodies and t...

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Bibliographic Details
Published in:Acta neuropathologica 2005-08, Vol.110 (2), p.113-119
Main Authors: Buss, A, Sellhaus, B, Wolmsley, A, Noth, J, Schwab, M E, Brook, G A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Blotting, Western
Brain research
Female
Glycoproteins
Humans
Immunohistochemistry
Investigations
Male
Microscopy, Confocal
Middle Aged
Monoclonal antibodies
Myelin Proteins - biosynthesis
Myelin Sheath - chemistry
Myelin Sheath - metabolism
Nervous system
Nervous System - metabolism
Nogo Proteins
Oligodendroglia - chemistry
Oligodendroglia - metabolism
Peptides
Proteins
RNA, Messenger - analysis
Spinal cord
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Summary:The distribution pattern of NOGO-A protein, an important axon growth inhibitory molecule and member of the reticulon family, has been investigated in the adult human brain, spinal cord, retina and dorsal root ganglia. Intense NOGO-A immunoreactivity was detected in oligodendroglial cell bodies and their myelin sheaths in nerve fibre tracts of the central nervous system. Furthermore, numerous populations of neurons in the brain and spinal cord expressed NOGO-A to a variable extent in their cell bodies and neurites, suggesting additional, as-yet-unknown, functions of this protein.
ISSN:0001-6322
1432-0533
DOI:10.1007/s00401-004-0942-z