Functional essentiality from topology features in metabolic networks: A case study in yeast

The relation between the position of mutations in Saccharomyces cerevisiae metabolic network and their lethality is the subject of this work. We represent the topology of the network by a directed graph: nodes are metabolites and arcs represent the reactions; a mutation corresponds to the removal of...

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Bibliographic Details
Published in:FEBS letters 2005-08, Vol.579 (21), p.4642-4646
Main Authors: Palumbo, Maria Concetta, Colosimo, Alfredo, Giuliani, Alessandro, Farina, Lorenzo
Format: Article
Language:English
Subjects:
Energy Metabolism
Enzymes - genetics
Enzymes - metabolism
Lethality
Models, Biological
Phenotype/genotype relations
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Systems biology
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Summary:The relation between the position of mutations in Saccharomyces cerevisiae metabolic network and their lethality is the subject of this work. We represent the topology of the network by a directed graph: nodes are metabolites and arcs represent the reactions; a mutation corresponds to the removal of all the arcs referring to the deleted enzyme. Using publicly available knock-out data, we show that lethality corresponds to the lack of alternative paths in the perturbed network linking the nodes affected by the enzyme deletion. Such feature is at the basis of the recently recognized importance of ‘marginal’ arcs of metabolic networks.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2005.07.033