The prediction of malignant cerebral infarction by molecular brain barrier disruption markers

Space-occupying brain edema is a life-threatening complication in patients with large hemispheric stroke. The aim of the study was to determine whether molecular markers of endothelial damage may help to predict secondary brain edema and, secondly, to identify patients who could benefit from aggress...

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Bibliographic Details
Published in:Stroke (1970) 2005-09, Vol.36 (9), p.1921-1926
Main Authors: SERENA, Joaquin, BLANCO, Miguel, CASTELLANOS, Mar, SILVA, Yolanda, VIVANCOS, Jose, MORO, Maria Angeles, LEIRA, Rogelio, LIZASOAIN, Ignacio, CASTILLO, José, DAVALOS, Antonio
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biomarkers
Blood-Brain Barrier
Blood. Blood coagulation. Reticuloendothelial system
Brain - pathology
Case-Control Studies
Edema
Female
Fibronectins - biosynthesis
Fibronectins - blood
gamma-Aminobutyric Acid - blood
Glutamic Acid - blood
Glycine - blood
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Hypothermia, Induced
Infarction, Middle Cerebral Artery - blood
Infarction, Middle Cerebral Artery - diagnosis
Infarction, Middle Cerebral Artery - surgery
Infarction, Middle Cerebral Artery - therapy
Interleukin-10 - blood
Interleukin-6 - blood
Male
Matrix Metalloproteinase 9 - biosynthesis
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Pharmacology. Drug treatments
Predictive Value of Tests
Retrospective Studies
Sensitivity and Specificity
Stroke - complications
Stroke - pathology
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
Tumor Necrosis Factor-alpha - biosynthesis
Vascular diseases and vascular malformations of the nervous system
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Summary:Space-occupying brain edema is a life-threatening complication in patients with large hemispheric stroke. The aim of the study was to determine whether molecular markers of endothelial damage may help to predict secondary brain edema and, secondly, to identify patients who could benefit from aggressive therapies such as decompressive hemicraniectomy or hypothermia. We studied 40 consecutive patients with malignant middle cerebral artery (MCA) infarction and 35 controls with massive MCA infarctions 16.6 microg/mL at admission is associated with the development of m-MCA infarction with high sensitivity and specificity, suggesting that c-Fn might be useful in therapeutic decision making.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000177870.14967.94