Circadian rhythmicity mediated by temporal regulation of the activity of p38 MAPK

Circadian clocks are composed of central oscillators, input pathways that transduce external information to the oscillators, and output pathways that allow the oscillators to temporally regulate cellular processes. Little is known about the output pathways. In this study, we show that the Neurospora...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2007-11, Vol.104 (46), p.18223-18228
Main Authors: Vitalini, Michael W, de Paula, Renato M, Goldsmith, Charles S, Jones, Carol A, Borkovich, Katherine A, Bell-Pedersen, Deborah
Format: Article
Language:English
Subjects:
abiotic stress
autophosphorylation
Biological Sciences
Cells
Circadian Rhythm
Enzyme Activation
Gene expression
Gene expression regulation
Genes
Genetic loci
Kinases
Messenger RNA
mitogen-activated protein kinase
mutants
Neurons
Neurospora crassa
Neurospora crassa - enzymology
Oscillators
Osmoregulation
Osmotic Pressure
p38 Mitogen-Activated Protein Kinases - metabolism
Phenotype
Phenotypes
Phosphorylation
protein phosphorylation
Signal transduction
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Circadian clocks are composed of central oscillators, input pathways that transduce external information to the oscillators, and output pathways that allow the oscillators to temporally regulate cellular processes. Little is known about the output pathways. In this study, we show that the Neurospora crassa osmosensing MAPK pathway, essential for osmotic stress responses, is a circadian output pathway that regulates daily rhythms in the expression of downstream genes. Rhythmic activation of the highly conserved stress-activated p38-type MAPK [Osmotically Sensitive-2 (OS-2)] by the N. crassa circadian clock allows anticipation and preparation for hyperosmotic stress and desiccation that begin at sunrise. These results suggest a conserved role for MAPK pathways in circadian rhythmicity.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0704900104