Activating Killer Cell Immunoglobulin-Like Receptor Gene KIR2DS1 Is Associated With Psoriatic Arthritis

Killer cell immunoglobulin-like receptor genotyping was performed on a cohort of American Caucasian patients with psoriasis to investigate any possible relationship between these chromosome 19 genes and autoimmune-linked disease. This patient cohort also contained a subgroup of patients who had been...

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Bibliographic Details
Published in:Human Immunology 2005-07, Vol.66 (7), p.836-841
Main Authors: Williams, Fionnuala, Meenagh, Ashley, Sleator, Carole, Cook, Daniel, Fernandez-Vina, Marcelo, Bowcock, Anne M., Middleton, Derek
Format: Article
Language:English
Subjects:
Arthritis, Psoriatic - genetics
Arthritis, Psoriatic - immunology
autoimmune disease
HLA-C Antigens - genetics
Humans
KIR2DS1
Models, Immunological
Phenotype
psoriasis
psoriatic arthritis
Receptors, Immunologic - genetics
Receptors, KIR
Receptors, KIR2DL1
Receptors, KIR2DL3
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Summary:Killer cell immunoglobulin-like receptor genotyping was performed on a cohort of American Caucasian patients with psoriasis to investigate any possible relationship between these chromosome 19 genes and autoimmune-linked disease. This patient cohort also contained a subgroup of patients who had been additionally diagnosed as positive for psoriatic arthritis (PsA). Because of the known association of human leucocyte antigen (HLA)-Cw*06 with psoriasis, the study concentrated on the five KIR genes that have HLA-C as their recognized ligand ( i.e., KIR2DL1, -2DL2, -2DL3, -2DS1, and -2DS2). An increase in the frequency of the activating KIR2DS1 gene was detected in the PsA patients, compared with psoriasis patients negative for PsA and an unaffected American Caucasian control group.
ISSN:0198-8859
1879-1166
1365-2567
DOI:10.1016/j.humimm.2005.04.005