The prevalence of human herpesvirus 6 in human sensory ganglia and its co-occurrence with alpha-herpesviruses

Human herpesvirus 6 (HHV-6) persists in the central nervous system, but its prevalence in the peripheral nervous system, a preferred latency site for herpesviruses, has not been studied. Using nested polymerase chain reaction (PCR), the authors determined the distribution of HHV-6 in human sensory g...

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Bibliographic Details
Published in:Journal of neurovirology 2007-10, Vol.13 (5), p.462-467
Main Authors: Hüfner, Katharina, Arbusow, Viktor, Himmelein, Susanne, Derfuss, Tobias, Sinicina, Inga, Strupp, Michael, Brandt, Thomas, Theil, Diethilde
Format: Article
Language:English
Subjects:
Autopsy
Biological and medical sciences
Ganglia, Sensory - pathology
Ganglia, Sensory - virology
Ganglia, Spinal - pathology
Ganglia, Spinal - virology
Herpes simplex virus 1
Herpesviridae - genetics
Herpesviridae - isolation & purification
Herpesvirus 6, Human - genetics
Herpesvirus 6, Human - isolation & purification
Human herpesvirus 6
Human viral diseases
Humans
Infectious diseases
Medical sciences
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Polymerase Chain Reaction
Trigeminal Ganglion - pathology
Trigeminal Ganglion - virology
Varicella-zoster virus
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral diseases of the nervous system
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Summary:Human herpesvirus 6 (HHV-6) persists in the central nervous system, but its prevalence in the peripheral nervous system, a preferred latency site for herpesviruses, has not been studied. Using nested polymerase chain reaction (PCR), the authors determined the distribution of HHV-6 in human sensory ganglia. HHV-6 was present in 30% of trigeminal, 40% of geniculate, 25% of vestibular, and 55% of dorsal root ganglia. It co-occurred with alpha-herpesviruses (herpes simplex virus type 1 or varicella-zoster virus) in 91% of the ganglia. As HHV-6 positivity did not depend on the presence of inflammatory cells, known to harbor the virus, HHV-6 probably resides in the ganglia themselves.
ISSN:1355-0284
1538-2443
DOI:10.1080/13550280701447059