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CD45‐Positive Blood Cells Give Rise to Uterine Epithelial Cells in Mice
The uterine endometrium is composed of epithelial and stromal cells, which undergo extensive degeneration and regeneration in every estrous cycle, and dramatic changes occur during pregnancy. The high turnover of cells requires a correspondingly high level of cell division by progenitor cells in the...
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| Published in: | Stem cells (Dayton, Ohio) Ohio), 2007-11, Vol.25 (11), p.2820-2826 |
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| container_end_page | 2826 |
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| container_title | Stem cells (Dayton, Ohio) |
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| creator | Bratincsák, András Brownstein, Michael J. Cassiani‐Ingoni, Riccardo Pastorino, Sandra Szalayova, Ildikó Tóth, Zsuzsanna E. Key, Sharon Németh, Krisztián Pickel, James Mezey, Éva |
| description | The uterine endometrium is composed of epithelial and stromal cells, which undergo extensive degeneration and regeneration in every estrous cycle, and dramatic changes occur during pregnancy. The high turnover of cells requires a correspondingly high level of cell division by progenitor cells in the uterus, but the character and source of these cells remain obscure. In the present study, using a novel transgenic mouse, we showed that CD45‐positive hematopoietic progenitor cells colonize the uterine epithelium and that in pregnancy more than 80% of the epithelium can derive from these cells. Since we also found green fluorescent protein (GFP)‐positive uterine endothelial cells in long‐term GFP bone marrow‐transplanted mice, we conclude that circulating CD45+ cells play an important role in regenerating the uterine epithelium.
Disclosure of potential conflicts of interest is found at the end of this article. |
| doi_str_mv | 10.1634/stemcells.2007-0301 |
| format | article |
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Disclosure of potential conflicts of interest is found at the end of this article.</description><subject>Adult stem cell</subject><subject>Aging - genetics</subject><subject>Animals</subject><subject>Cell Differentiation - genetics</subject><subject>Endometrium</subject><subject>Epithelial Cells - cytology</subject><subject>Epithelial Cells - physiology</subject><subject>Female</subject><subject>Hematopoietic stem cell</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>Leukocyte Common Antigens - biosynthesis</subject><subject>Leukocyte Common Antigens - blood</subject><subject>Leukocyte Common Antigens - genetics</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Pregnancy</subject><subject>Regeneration</subject><subject>Uterus - cytology</subject><subject>Uterus - physiology</subject><issn>1066-5099</issn><issn>1549-4918</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkM1Kw0AURgdRbK0-gSBZuUu9k_nJDK401lpoUbRdhyRzgyNpUzOp0p2P4DP6JCY06FJXcxnOdxaHkFMKQyoZv3A1LjMsCjcMAEIfGNA90qeCa59rqvabG6T0BWjdI0fOvQBQLpQ6JD0aSiElZ30yiW64-Pr4fCidre0betdFWRovar3euP14tA69uvQWNVZ2hd5obetnLGxSdJRdeTOb4TE5yJPC4Un3DsjidjSP7vzp_XgSXU39jOsQ_FCblOaMilRKUAlNmVEqMwooQwEmByoDjgxTrVhiAIFLZFmYQmLyQBlgA3K-866r8nWDro6X1rUdkhWWGxdLxZXSOvgTbKoxykPegGwHZlXpXIV5vK7sMqm2MYW4TR3_pG5HYdymblZnnX6TLtH8brq2DXC5A95tgdv_OOOn-WgWiEAFwL4BlBWOfQ</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>Bratincsák, András</creator><creator>Brownstein, Michael J.</creator><creator>Cassiani‐Ingoni, Riccardo</creator><creator>Pastorino, Sandra</creator><creator>Szalayova, Ildikó</creator><creator>Tóth, Zsuzsanna E.</creator><creator>Key, Sharon</creator><creator>Németh, Krisztián</creator><creator>Pickel, James</creator><creator>Mezey, Éva</creator><general>John Wiley & Sons, Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200711</creationdate><title>CD45‐Positive Blood Cells Give Rise to Uterine Epithelial Cells in Mice</title><author>Bratincsák, András ; Brownstein, Michael J. ; Cassiani‐Ingoni, Riccardo ; Pastorino, Sandra ; Szalayova, Ildikó ; Tóth, Zsuzsanna E. ; Key, Sharon ; Németh, Krisztián ; Pickel, James ; Mezey, Éva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4970-79db1f315b6608a1b3d88cd8013e50df01624e3eb983ad0e046e3c7b0adf28d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult stem cell</topic><topic>Aging - genetics</topic><topic>Animals</topic><topic>Cell Differentiation - genetics</topic><topic>Endometrium</topic><topic>Epithelial Cells - cytology</topic><topic>Epithelial Cells - physiology</topic><topic>Female</topic><topic>Hematopoietic stem cell</topic><topic>Hematopoietic Stem Cells - metabolism</topic><topic>Hematopoietic Stem Cells - physiology</topic><topic>Leukocyte Common Antigens - biosynthesis</topic><topic>Leukocyte Common Antigens - blood</topic><topic>Leukocyte Common Antigens - genetics</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Pregnancy</topic><topic>Regeneration</topic><topic>Uterus - cytology</topic><topic>Uterus - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bratincsák, András</creatorcontrib><creatorcontrib>Brownstein, Michael J.</creatorcontrib><creatorcontrib>Cassiani‐Ingoni, Riccardo</creatorcontrib><creatorcontrib>Pastorino, Sandra</creatorcontrib><creatorcontrib>Szalayova, Ildikó</creatorcontrib><creatorcontrib>Tóth, Zsuzsanna E.</creatorcontrib><creatorcontrib>Key, Sharon</creatorcontrib><creatorcontrib>Németh, Krisztián</creatorcontrib><creatorcontrib>Pickel, James</creatorcontrib><creatorcontrib>Mezey, Éva</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Stem cells (Dayton, Ohio)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bratincsák, András</au><au>Brownstein, Michael J.</au><au>Cassiani‐Ingoni, Riccardo</au><au>Pastorino, Sandra</au><au>Szalayova, Ildikó</au><au>Tóth, Zsuzsanna E.</au><au>Key, Sharon</au><au>Németh, Krisztián</au><au>Pickel, James</au><au>Mezey, Éva</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD45‐Positive Blood Cells Give Rise to Uterine Epithelial Cells in Mice</atitle><jtitle>Stem cells (Dayton, Ohio)</jtitle><addtitle>Stem Cells</addtitle><date>2007-11</date><risdate>2007</risdate><volume>25</volume><issue>11</issue><spage>2820</spage><epage>2826</epage><pages>2820-2826</pages><issn>1066-5099</issn><eissn>1549-4918</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The uterine endometrium is composed of epithelial and stromal cells, which undergo extensive degeneration and regeneration in every estrous cycle, and dramatic changes occur during pregnancy. The high turnover of cells requires a correspondingly high level of cell division by progenitor cells in the uterus, but the character and source of these cells remain obscure. In the present study, using a novel transgenic mouse, we showed that CD45‐positive hematopoietic progenitor cells colonize the uterine epithelium and that in pregnancy more than 80% of the epithelium can derive from these cells. Since we also found green fluorescent protein (GFP)‐positive uterine endothelial cells in long‐term GFP bone marrow‐transplanted mice, we conclude that circulating CD45+ cells play an important role in regenerating the uterine epithelium.
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| identifier | ISSN: 1066-5099 |
| ispartof | Stem cells (Dayton, Ohio), 2007-11, Vol.25 (11), p.2820-2826 |
| issn | 1066-5099 1549-4918 |
| language | eng |
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| source | Wiley; Oxford Journals Online |
| subjects | Adult stem cell Aging - genetics Animals Cell Differentiation - genetics Endometrium Epithelial Cells - cytology Epithelial Cells - physiology Female Hematopoietic stem cell Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - physiology Leukocyte Common Antigens - biosynthesis Leukocyte Common Antigens - blood Leukocyte Common Antigens - genetics Mice Mice, Inbred C57BL Mice, Transgenic Pregnancy Regeneration Uterus - cytology Uterus - physiology |
| title | CD45‐Positive Blood Cells Give Rise to Uterine Epithelial Cells in Mice |
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