CD45‐Positive Blood Cells Give Rise to Uterine Epithelial Cells in Mice

The uterine endometrium is composed of epithelial and stromal cells, which undergo extensive degeneration and regeneration in every estrous cycle, and dramatic changes occur during pregnancy. The high turnover of cells requires a correspondingly high level of cell division by progenitor cells in the...

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Bibliographic Details
Published in:Stem cells (Dayton, Ohio) Ohio), 2007-11, Vol.25 (11), p.2820-2826
Main Authors: Bratincsák, András, Brownstein, Michael J., Cassiani‐Ingoni, Riccardo, Pastorino, Sandra, Szalayova, Ildikó, Tóth, Zsuzsanna E., Key, Sharon, Németh, Krisztián, Pickel, James, Mezey, Éva
Format: Article
Language:English
Subjects:
Adult stem cell
Aging - genetics
Animals
Cell Differentiation - genetics
Endometrium
Epithelial Cells - cytology
Epithelial Cells - physiology
Female
Hematopoietic stem cell
Hematopoietic Stem Cells - metabolism
Hematopoietic Stem Cells - physiology
Leukocyte Common Antigens - biosynthesis
Leukocyte Common Antigens - blood
Leukocyte Common Antigens - genetics
Mice
Mice, Inbred C57BL
Mice, Transgenic
Pregnancy
Regeneration
Uterus - cytology
Uterus - physiology
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Summary:The uterine endometrium is composed of epithelial and stromal cells, which undergo extensive degeneration and regeneration in every estrous cycle, and dramatic changes occur during pregnancy. The high turnover of cells requires a correspondingly high level of cell division by progenitor cells in the uterus, but the character and source of these cells remain obscure. In the present study, using a novel transgenic mouse, we showed that CD45‐positive hematopoietic progenitor cells colonize the uterine epithelium and that in pregnancy more than 80% of the epithelium can derive from these cells. Since we also found green fluorescent protein (GFP)‐positive uterine endothelial cells in long‐term GFP bone marrow‐transplanted mice, we conclude that circulating CD45+ cells play an important role in regenerating the uterine epithelium. Disclosure of potential conflicts of interest is found at the end of this article.
ISSN:1066-5099
1549-4918
DOI:10.1634/stemcells.2007-0301