Bispectral Index™ values are higher during halothane vs. sevoflurane anesthesia in children, but not in infants

Background:  Previously, we have shown in adult patients that bispectral index score (BIS) values are significantly higher during halothane anesthesia (53–61 units) as compared with those observed during equipotent concentrations of sevoflurane (39–43 units). Because halothane is frequently used in...

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Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2005-09, Vol.49 (8), p.1084-1087
Main Authors: Edwards, J. J., Soto, R. G., Bedford, R. F.
Format: Article
Language:English
Subjects:
Age Factors
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Inhalation - pharmacology
Biological and medical sciences
bispectral index score
Child
Child, Preschool
consciousness
Electroencephalography - drug effects
halothane
Halothane - pharmacology
Humans
Infant
inhalation
Medical sciences
Methyl Ethers - pharmacology
Reference Values
sevoflurane
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Summary:Background:  Previously, we have shown in adult patients that bispectral index score (BIS) values are significantly higher during halothane anesthesia (53–61 units) as compared with those observed during equipotent concentrations of sevoflurane (39–43 units). Because halothane is frequently used in the pediatric setting, we tested the hypothesis that BIS values observed in children might also be higher during general anesthesia with halothane than with sevoflurane. Methods:  Forty‐one healthy, unpremedicated pediatric patients scheduled for elective operations received either halothane or sevoflurane titrated as appropriate for surgical stimulation. Results:  During maintenance sevoflurane anesthesia (n = 20), the mean BIS values and percent end‐tidal concentrations were 44 ± 14 and 2.1 ± 0.6, respectively, whereas for the halothane group (n = 21) the corresponding values were 61 ± 7 and 1.1 ± 0.4, respectively. Conclusion:  These findings suggest that BIS values are higher during halothane vs. sevoflurane anesthesia in children, but not in infants
ISSN:0001-5172
1399-6576
DOI:10.1111/j.1399-6576.2005.00813.x