Sinulochmodins A−C, Three Novel Terpenoids from the Soft Coral Sinularia lochmodes

An unprecedented C,C-linked dimeric norcembranoid (sinulochmodin A, 1), a novel isocembranoid (sinulochmodin B, 2), and a novel yonarane norditerpenoid (sinulochmodin C, 3) were isolated from the soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectro...

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Bibliographic Details
Published in:Organic letters 2005-08, Vol.7 (17), p.3813-3816
Main Authors: Tseng, Yen-Ju, Ahmed, Atallah F, Dai, Chang-Feng, Chiang, Michael Y, Sheu, Jyh-Horng
Format: Article
Language:English
Subjects:
Animals
Anthozoa - chemistry
Diterpenes - chemistry
Diterpenes - isolation & purification
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
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Summary:An unprecedented C,C-linked dimeric norcembranoid (sinulochmodin A, 1), a novel isocembranoid (sinulochmodin B, 2), and a novel yonarane norditerpenoid (sinulochmodin C, 3) were isolated from the soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic analysis and on the basis of the absolute structures of two related norditerpenoids (4 and 5), which were determined for the first time by a modified Mosher method. A plausible pathway for the biosynthesis of 1 and 3−5 from 2 was postulated.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol051513j