Apoptosis in the kidneys of patients with type II diabetic nephropathy

The occurrence and extent of apoptosis in the kidneys of patients with diabetic nephropathy is largely unknown. We evaluated apoptosis in renal biopsies obtained from patients with early or advanced type II diabetic nephropathy. Apoptosis was about 6- and 3-fold higher, respectively, in glomeruli an...

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Bibliographic Details
Published in:Kidney international 2007-11, Vol.72 (10), p.1262-1272
Main Authors: Verzola, D., Gandolfo, M.T., Ferrario, F., Rastaldi, M.P., Villaggio, B., Gianiorio, F., Giannoni, M., Rimoldi, L., Lauria, F., Miji, M., Deferrari, G., Garibotto, G.
Format: Article
Language:English
Subjects:
anti-ssDNA
apoptosis
Apoptosis - physiology
Biological and medical sciences
Biopsy
Case-Control Studies
Cholesterol, LDL - blood
diabetes mellitus
Diabetes Mellitus, Type 2 - pathology
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Diabetic Nephropathies - pathology
Diabetic Nephropathies - physiopathology
diabetic nephropathy
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fas
Fas Ligand Protein - metabolism
fas Receptor - metabolism
Glomerular Filtration Rate
Glycated Hemoglobin A - analysis
Humans
Immunohistochemistry
Kidney - pathology
Kidney - surgery
Kidney Glomerulus - metabolism
Kidney Tubules - blood supply
Kidneys
Medical sciences
Multivariate Analysis
Nephrology. Urinary tract diseases
p38 MAPK
p38 Mitogen-Activated Protein Kinases - metabolism
Up-Regulation
Urinary system involvement in other diseases. Miscellaneous
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Summary:The occurrence and extent of apoptosis in the kidneys of patients with diabetic nephropathy is largely unknown. We evaluated apoptosis in renal biopsies obtained from patients with early or advanced type II diabetic nephropathy. Apoptosis was about 6- and 3-fold higher, respectively, in glomeruli and tubules in kidneys of patients with early nephropathy than in the normal kidney and this was not further increased in advanced diabetic nephropathy. Glomerular apoptosis was related directly to hemoglobin A1c and systolic blood pressure, whereas tubular cell apoptosis correlated to diabetes duration and low-density lipoprotein-cholesterol. Fas, Fas ligand, and p38 mitogen-activated protein kinase expressions were enhanced in glomeruli and tubules; however, this did not correlate with apoptosis. In patients with proteinuria, apoptosis was associated with the subsequent loss of kidney function. When these parameters were subjected to multivariate analysis, only glomerular apoptosis retained a significant independent predictive value. Our findings suggest that apoptosis might be a clinically relevant mechanism of glomerular and tubular cell loss in proteinuric type II diabetic patients.
ISSN:0085-2538
1523-1755
DOI:10.1038/sj.ki.5002531