Microbiologic Changes Following Administration of Locally Delivered Doxycycline in Smokers: A 15‐Month Follow‐Up

Background: Additional clinical benefits have been reported with the use of locally delivered antimicrobials in the treatment of smokers; however, long‐term changes in the subgingival microbiota following the use of these drugs in smokers have not been documented. The aim of this study was to evalua...

Full description

Saved in:
Bibliographic Details
Published in:Journal of periodontology (1970) 2007-11, Vol.78 (11), p.2143-2149
Main Authors: Shaddox, Luciana M., Andia, Denise Carleto, Casati, Marcio Zaffalon, Nociti, Francisco Humberto, Sallum, Enilson Antonio, Gollwitzer, Jennifer, Walker, Clay B.
Format: Article
Language:English
Subjects:
Actinomyces - drug effects
Actinomyces - isolation & purification
Adult
Anti-Bacterial Agents - administration & dosage
Biological and medical sciences
Chronic Disease
Dental Plaque - drug therapy
Dental Plaque - microbiology
Dental Scaling
Dentistry
DNA Probes
Doxycycline
Doxycycline - administration & dosage
Female
Follow-Up Studies
Humans
Male
Medical sciences
microbiology
periodontal disease
Periodontitis - drug therapy
Porphyromonas gingivalis - drug effects
Porphyromonas gingivalis - isolation & purification
Root Planing
Smoking
Statistics, Nonparametric
therapy
Tobacco, tobacco smoking
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Additional clinical benefits have been reported with the use of locally delivered antimicrobials in the treatment of smokers; however, long‐term changes in the subgingival microbiota following the use of these drugs in smokers have not been documented. The aim of this study was to evaluate long‐term microbiologic changes following locally delivered doxycycline in the treatment of smokers. Methods: Sixteen smokers with chronic periodontitis presenting a minimum of four pockets (probing depth ≥5 mm) were selected. Patients were assigned randomly to receive scaling and root planing (SRP) or SRP and local doxycycline (SRP‐D). Patients were treated at baseline and 12 months. Subgingival plaque samples were collected at baseline; 3, 6, and 12 months; and 45 and 90 days following retreatment. Polymerase chain reaction and DNA–DNA hybridization analyses were performed to detect the presence of selected periodontal pathogens. Results: The reduction in the number of sites positive for Porphyromonas gingivalis and Tannerella forsythia (previously T. forsythensis) was statistically significant for SRP‐D at 3 months (68% and 41.3%, respectively) and for SRP at 6 months (75% and 52%, respectively) following treatment. The SRP group showed a greater frequency of P. gingivalis than the SRP‐D group at 3 months (58% and 25%, respectively). There also was a greater reduction in the frequency of P. gingivalis at 3 months following retreatment with SRP‐D compared to SRP (47% and 8%, respectively). Conclusion: In smokers, adjunctive local doxycycline resulted in a greater reduction in the frequency of P. gingivalis following initial and supportive therapy compared to conventional treatment.
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2007.070189