Borderzone Contractile Dysfunction Is Transiently Attenuated and Left Ventricular Structural Remodeling Is Markedly Reduced Following Reperfused Myocardial Infarction in Inducible Nitric Oxide Synthase Knockout Mice

Borderzone Contractile Dysfunction Is Transiently Attenuated and Left Ventricular Structural Remodeling Is Markedly Reduced Following Reperfused Myocardial Infarction in Inducible Nitric Oxide Synthase Knockout Mice Wesley D. Gilson, Frederick H. Epstein, Zequan Yang, Yaqin Xu, Konkal-Matt R. Prasad...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American College of Cardiology 2007-10, Vol.50 (18), p.1799-1807
Main Authors: Gilson, Wesley D., PhD, Epstein, Frederick H., PhD, Yang, Zequan, MD, PhD, Xu, Yaqin, MD, PhD, Prasad, Konkal-Matt R., PhD, Toufektsian, Marie-Claire, PhD, Laubach, Victor E., PhD, French, Brent A., PhD
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular
Coronary heart disease
Data analysis
Heart
Heart attacks
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Internal Medicine
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Knockout
Molecular weight
Myocardial Infarction - complications
Myocardial Infarction - metabolism
Myocardial Infarction - therapy
Myocardial Reperfusion
Myocarditis. Cardiomyopathies
Nitrates
Nitric oxide
Nitric Oxide Synthase Type II - metabolism
Plasma
Rodents
Stroke Volume - physiology
Studies
Time Factors
Ventricular Dysfunction, Left - etiology
Ventricular Dysfunction, Left - metabolism
Ventricular Dysfunction, Left - pathology
Ventricular Remodeling - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Borderzone Contractile Dysfunction Is Transiently Attenuated and Left Ventricular Structural Remodeling Is Markedly Reduced Following Reperfused Myocardial Infarction in Inducible Nitric Oxide Synthase Knockout Mice Wesley D. Gilson, Frederick H. Epstein, Zequan Yang, Yaqin Xu, Konkal-Matt R. Prasad, Marie-Claire Toufektsian, Victor E. Laubach, Brent A. French Inducible nitric oxide synthase (iNOS) contributes to global left ventricular (LV) dysfunction after myocardial infarction (MI). Immunohistochemistry reveals that iNOS expression is abundant throughout the hearts of wild-type (WT) mice after MI, particularly in the infarct borderzone. In iNOS knockout mice, we show, using cardiac magnetic resonance imaging, that although infarct size at 24 h after MI is similar to WT mice, borderzone contractile function is significantly improved at 7 days after MI and LV remodeling and the circumferential extent of wall thinning is significantly reduced at 7 and 28 days after MI. Thus, iNOS expression contributes importantly to post-infarction contractile dysfunction and LV remodeling.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.07.047