Automatic detection of movement disorders using recordings of rapid alternating movements

The present work assesses the potential of rapid alternating movement analysis for detecting movement disorders like Parkinson's disease. Rapid alternating wrist movements were recorded by a diadochokinesimeter for patients with Parkinson's disease ( n = 10) and healthy controls ( n = 20)....

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Bibliographic Details
Published in:Journal of neuroscience methods 2005-08, Vol.146 (2), p.183-190
Main Authors: Fimbel, Eric J., Domingo, Pedro Perez, Lamoureux, Daniel, Beuter, Anne
Format: Article
Language:English
Subjects:
Adult
Biomechanical Phenomena - instrumentation
Biomechanical Phenomena - methods
Electrodiagnosis - instrumentation
Electrodiagnosis - methods
Female
Forearm - physiology
Humans
Jerk
Male
Middle Aged
Movement - physiology
Parkinson Disease - diagnosis
Parkinson Disease - physiopathology
Parkinson's disease
Rapid alternating movement
Signal Processing, Computer-Assisted - instrumentation
Smoothness
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Summary:The present work assesses the potential of rapid alternating movement analysis for detecting movement disorders like Parkinson's disease. Rapid alternating wrist movements were recorded by a diadochokinesimeter for patients with Parkinson's disease ( n = 10) and healthy controls ( n = 20). An index of irregularity was computed for each individual as the density of jerk singularities (i.e. zero-crossings) during the movements. Several scales of analysis (i.e. “coarseness”) were used for detecting the jerk events and two methods were compared for all of these scales: (1) automatic classification by means of a threshold that optimally separates the indexes of irregularity of the patients from those of the controls, and (2) statistical decision (normal or abnormal) based upon a distribution of indexes of irregularity obtained from a large population of normal subjects. The results showed that (1) two scales of analysis were sufficient and that (2) both methods presented similar performances (e.g. sensitivity = 1.00, specificity = 0.85, efficiency = 0.90). However, statistical decision should be preferred because of its simplicity. The possibility of automatic detection of movement disorders from alternating movements is discussed.
ISSN:0165-0270
1872-678X
DOI:10.1016/j.jneumeth.2005.02.007