Influence of Psychological Factors on Risk of Temporomandibular Disorders

Psychological characteristics potentially may be a cause or consequence of temporomandibular disorder (TMD). We hypothesized that psychological characteristics associated with pain sensitivity would influence risk of first-onset TMD, but the effect could be attributed to variation in the gene encodi...

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Bibliographic Details
Published in:Journal of dental research 2007-11, Vol.86 (11), p.1120-1125
Main Authors: Slade, G.D., Diatchenko, L., Bhalang, K., Sigurdsson, A., Fillingim, R.B., Belfer, I., Max, M.B., Goldman, D., Maixner, W.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Catechol O-Methyltransferase - genetics
Cohort Studies
Dentistry
Depression - complications
Female
Humans
Mood Disorders - complications
Pain Measurement
Pain Threshold - psychology
Polymorphism, Single Nucleotide
Prospective Studies
Risk Factors
Stress, Psychological - complications
Surveys and Questionnaires
Temporomandibular Joint Disorders - complications
Temporomandibular Joint Disorders - enzymology
Temporomandibular Joint Disorders - genetics
Temporomandibular Joint Disorders - psychology
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Summary:Psychological characteristics potentially may be a cause or consequence of temporomandibular disorder (TMD). We hypothesized that psychological characteristics associated with pain sensitivity would influence risk of first-onset TMD, but the effect could be attributed to variation in the gene encoding catechol-O-methyltransferase (COMT). We undertook a prospective cohort study of healthy female volunteers aged 18–34 yrs. At baseline, participants were genotyped, they completed psychological questionnaires, and underwent quantitative sensory testing to determine pain sensitivity. We followed 171 participants for up to three years, and 8.8% of them were diagnosed with first-onset TMD. Depression, perceived stress, and mood were associated with pain sensitivity and were predictive of 2- to 3-fold increases in risk of TMD (P < 0.05). However, the magnitude of increased TMD risk due to psychological factors remained unchanged after adjustment for the COMT haplotype. Psychological factors linked to pain sensitivity influenced TMD risk independently of the effects of the COMT haplotype on TMD risk.
ISSN:0022-0345
1544-0591
DOI:10.1177/154405910708601119