Hemodynamic and oxidative stress profile after exercise in type 2 diabetes

Abstract This study investigated the effect of an acute bout of exercise (>85% V O 2 Max ) on biochemical, hemodynamic and oxidative stress variables in sedentary and physically active subjects with type 2 diabetes (T2D). Blood measurements were taken before and after a treadmill test on 12 seden...

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Published in:Diabetes research and clinical practice 2007-03, Vol.75 (3), p.285-291
Main Authors: Villa-Caballero, L, Nava-Ocampo, A.A, Frati-Munari, A.C, Rodríguez de León, S.M, Becerra–Pérez, A.R, Ceja, R.M, Campos-Lara, M.G, Ponce-Monter, H.A
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - analysis
Blood Pressure - physiology
Cardiovascular risk
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - physiopathology
Diastole
Endocrinology & Metabolism
Exercise
Exercise Test
Female
formula omitted
Heart Rate
Humans
Male
Middle Aged
Oxidative stress
Oxidative Stress - physiology
Reference Values
Systole
Thiobarbituric Acid Reactive Substances - analysis
Type 2 diabetes
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Summary:Abstract This study investigated the effect of an acute bout of exercise (>85% V O 2 Max ) on biochemical, hemodynamic and oxidative stress variables in sedentary and physically active subjects with type 2 diabetes (T2D). Blood measurements were taken before and after a treadmill test on 12 sedentary non-diabetes subjects (ND), 12 sedentary type 2 diabetes (T2S) and 9 physically active T2D subjects (T2DA). T2DS subjects before and after the treadmill test showed a higher plasma glucose (123.2 ± 19.0 mg/dL versus 108.9 ± 16.8 mg/dL, p < 0.001), HbA1C (8.7 ± 2.4% versus 7.3 ± 1.2%, p < 0.001) and body fat% (21.3 ± 5.7% versus 34.6 ± 4.5%, p < 0.001) than T2DA subjects. T2DA had higher V O 2 Max (37.7 ± 3.5 versus 29.5 ± 3.2, p < 0.05), time on treadmill (22.3 ± 2.1 min versus 16.1 ± 2.1 min, p < 0.05), hemoglobin (17.9 ± 0.9 g/dL, p < 0.05) and lower blood pressure levels in comparison to ND and T2DS subjects. Thiobarbituric acid substances (TBARS) in T2DS were higher than in T2DA subjects (0.27 ± 0.1 nmol/mL versus 0.21 ± 0.1 nmol/mL, p < 0.05). Glutathione (GSH) levels were similar among the groups. Physically active type 2 diabetes subjects had a more favorable biochemical, hemodynamic and oxidative stress profile than sedentary subjects. The coexistence of a poor cardiopulmonary performance and high oxidative stress environment can determine a profile of high risk for serious cardiovascular events in patients with diabetes.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2006.07.011