Clinical Outcomes and CD4 Cell Response in Children Receiving Antiretroviral Therapy at Primary Health Care Facilities in Zambia

CONTEXT The Zambian Ministry of Health provides pediatric antiretroviral therapy (ART) at primary care clinics in Lusaka, where, despite scale-up of perinatal prevention efforts, many children are already infected with the human immunodeficiency virus (HIV). OBJECTIVE To report early clinical and im...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2007-10, Vol.298 (16), p.1888-1899
Main Authors: Bolton-Moore, Carolyn, Mubiana-Mbewe, Mwangelwa, Cantrell, Ronald A, Chintu, Namwinga, Stringer, Elizabeth M, Chi, Benjamin H, Sinkala, Moses, Kankasa, Chipepo, Wilson, Craig M, Wilfert, Catherine M, Mwango, Albert, Levy, Jens, Abrams, Elaine J, Bulterys, Marc, Stringer, Jeffrey S. A
Format: Article
Language:English
Subjects:
Antiretroviral drugs
Antiretroviral Therapy, Highly Active
Biological and medical sciences
CD4 Lymphocyte Count
Child
Child, Preschool
Clinical outcomes
Community Health Services
Female
General aspects
Government Programs
HIV
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - mortality
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infant
Infectious diseases
Male
Medical sciences
Mortality
Pediatrics
Primary care
Survival Analysis
Treatment Outcome
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Weight Gain
Zambia
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Summary:CONTEXT The Zambian Ministry of Health provides pediatric antiretroviral therapy (ART) at primary care clinics in Lusaka, where, despite scale-up of perinatal prevention efforts, many children are already infected with the human immunodeficiency virus (HIV). OBJECTIVE To report early clinical and immunologic outcomes of children enrolled in the pediatric treatment program. DESIGN, SETTING, AND PATIENTS Open cohort assessment using routinely collected clinical and outcome data from an electronic medical record system in use at 18 government primary health facilities in Lusaka, Zambia. Care was provided primarily by nurses and clinical officers (“physician extenders” akin to physician assistants in the United States). Patients were children (
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.298.16.1888