Is measurement of IgM and IgA rheumatoid factors (RF) in juvenile rheumatoid arthritis clinically useful?

The prevalence and clinical relevance of IgM and IgA RF detected by ELISA were studied in 91 patients with juvenile rheumatoid arthritis (JRA) and 45 healthy children. IgM and IgA RF were detected, respectively, in 33 and 44% of the patients, compared to 6.7 and 15.6% of the healthy children (p = 0....

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Published in:Rheumatology international 2007-02, Vol.27 (4), p.345-349
Main Authors: Ferreira, Rosa A, Silva, Carlos H M, Silva, Deise A O, Sopelete, Monica C, Kiss, Maria H B, Mineo, Jose R, Ferriani, Virginia P L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Arthritis, Juvenile - blood
Arthritis, Juvenile - pathology
Biomarkers - blood
Case-Control Studies
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin A - blood
Immunoglobulin M - blood
Immunologic Tests - methods
Male
Medical research
Rheumatoid arthritis
Rheumatoid Factor - blood
Rheumatoid Factor - immunology
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Summary:The prevalence and clinical relevance of IgM and IgA RF detected by ELISA were studied in 91 patients with juvenile rheumatoid arthritis (JRA) and 45 healthy children. IgM and IgA RF were detected, respectively, in 33 and 44% of the patients, compared to 6.7 and 15.6% of the healthy children (p = 0.001 and 0.0006, respectively). The frequency of IgM RF was significantly higher in patients with polyarticular (52%) as compared to systemic onset JRA (21%; p = 0.04). Five out of ninety-one patients and none of the control group were IgM RF positive by the latex test. High levels of IgM RF were detected more frequently in patients with active disease (p = 0.01) and positive latex agglutination test (p < 0.001) and had a marginally significant association with severe radiological deformities (p = 0.05). The presence of IgA RF was associated with active disease in polyarticular onset JRA children (p = 0.04). In conclusion, high levels of IgM RF and the detection of IgA RF can be useful in assessing clinical activity in a subset of patients with JRA.
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-006-0221-5