An introduction to Toll‐like receptors and their possible role in the initiation of labour

Toll‐like receptors (TLR) have emerged as key upstream mediators of inflammation at many tissue sites in humans. Inflammatory processes are involved in the process of parturition suggesting that TLR activity within gestation‐associated tissues might have an important role in the initiation and/or ma...

Full description

Saved in:
Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2007-11, Vol.114 (11), p.1326-1334
Main Authors: Patni, S, Flynn, P, Wynen, LP, Seager, AL, Morgan, G, White, JO, Thornton, CA
Format: Article
Language:English
Subjects:
Amnion - physiology
Biological and medical sciences
Cell Communication - physiology
Cervix Uteri - physiology
Cytokines
Cytokines - physiology
Decidua - physiology
Extraembryonic Membranes - physiology
Female
Gynecology. Andrology. Obstetrics
human
Humans
Labor, Obstetric - physiology
Medical sciences
Obstetric Labor, Premature - etiology
Obstetric Labor, Premature - metabolism
parturition
Placenta - physiology
Pregnancy
preterm
Toll-Like Receptors - physiology
toll‐like receptors
Uterine Contraction - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Toll‐like receptors (TLR) have emerged as key upstream mediators of inflammation at many tissue sites in humans. Inflammatory processes are involved in the process of parturition suggesting that TLR activity within gestation‐associated tissues might have an important role in the initiation and/or maintenance of normal term labour and in various pathological states of pregnancy such as infection‐associated preterm labour. Either TLRs or their signalling molecules might be excellent therapeutic targets for prevention of preterm labour.
ISSN:1470-0328
1471-0528
DOI:10.1111/j.1471-0528.2007.01488.x