The Additive Effects of Minoxidil and Retinol on Human Hair Growth in Vitro

Minoxidil enhances hair growth by prolonging the anagen phase and induces new hair growth in androgenetic alopecia (AGA), whereas retinol significantly improves scalp skin condition and promotes hair growth. We investigated the combined effects of minoxidil and retinol on human hair growth in vitro...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2007, Vol.30(1), pp.21-26
Main Authors: Yoo, Hyeon Gyeong, Chang, In-Young, Pyo, Hyun Keol, Kang, Yong Jung, Lee, Seung Ho, Kwon, Oh Sang, Cho, Kwang Hyun, Eun, Hee Chul, Kim, Kyu Han
Format: Article
Language:eng ; jpn
Subjects:
Adult
Alopecia - drug therapy
Apoptosis - drug effects
bcl-2-Associated X Protein - metabolism
Cell Line
Cell Proliferation - drug effects
dermal papilla cell
Dose-Response Relationship, Drug
Drug Therapy, Combination
Extracellular Signal-Regulated MAP Kinases - metabolism
Hair - drug effects
Hair - growth & development
Hair - metabolism
Hair Follicle - drug effects
Hair Follicle - growth & development
Hair Follicle - metabolism
hair follicle organ culture
hair growth
Humans
keratinocyte
Keratinocytes - drug effects
Male
minoxidil
Minoxidil - pharmacology
Minoxidil - therapeutic use
Organ Culture Techniques
Phosphorylation - drug effects
Proto-Oncogene Proteins c-akt - metabolism
Proto-Oncogene Proteins c-bcl-2 - metabolism
retinol
Skin - cytology
Skin - drug effects
Skin - metabolism
Vitamin A - pharmacology
Vitamin A - therapeutic use
Vitamins - pharmacology
Vitamins - therapeutic use
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Summary:Minoxidil enhances hair growth by prolonging the anagen phase and induces new hair growth in androgenetic alopecia (AGA), whereas retinol significantly improves scalp skin condition and promotes hair growth. We investigated the combined effects of minoxidil and retinol on human hair growth in vitro and on cultured human dermal papilla cells (DPCs) and epidermal keratinocytes (HaCaT). The combination of minoxidil and retinol additively promoted hair growth in hair follicle organ cultures. In addition, minoxidil plus retinol more effectively elevated phosphorylated Erk, phosphorylated Akt levels, and the Bcl-2/Bax ratio than minoxidil alone in DPCs and HaCaT. We found that the significant hair shaft elongation demonstrated after minoxidil plus retinol treatment would depend on the dual kinetics associated with the activations of Erk- and Akt-dependent pathways and the prevention of apoptosis by increasing the Bcl-2/Bax ratio.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.30.21