Synthesis and characterization of biocompatible Fe3O4 nanoparticles

In this study, magnetite (Fe3O4) nanoparticles with a size range of 8–20 nm were prepared by the modified controlled chemical coprecipitation method from the solution of ferrous/ferric mixed salt‐solution in alkaline medium. In the process, two kinds of surfactant (sodium oleate and polyethylene gly...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2007-02, Vol.80A (2), p.333-341
Main Authors: Sun, Jing, Zhou, Shaobing, Hou, Peng, Yang, Yuan, Weng, Jie, Li, Xiaohong, Li, Mingyuan
Format: Article
Language:English
Subjects:
3T3 Cells
Animals
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Cell Line
Cell Survival
chemical coprecipitation
Chemical Precipitation
cytotoxicity
Ferrosoferric Oxide - chemistry
magnetite
Mice
Microscopy, Electron
nanoparticles
Nanoparticles - chemistry
Oleic Acid
polyethylene glycol
sodium oleate
Spectroscopy, Fourier Transform Infrared
Surface-Active Agents
surfactant
X-Ray Diffraction
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, magnetite (Fe3O4) nanoparticles with a size range of 8–20 nm were prepared by the modified controlled chemical coprecipitation method from the solution of ferrous/ferric mixed salt‐solution in alkaline medium. In the process, two kinds of surfactant (sodium oleate and polyethylene glycol) were studied; then, sodium oleate was chosen as the apt surfactant to attain ultrafine, nearly spherical and well‐dispersed (water‐base) Fe3O4 nanoparticles, which had well magnetic properties. The size and size distribution of nanoparticles were determined by particle size analyzer. And the magnetite nanoparticles was characterized by X‐ray powder diffraction (XRD) analysis, transmission electron microscopy (TEM), electron diffraction (ED) photography, Fourier transform infrared spectrometer (FT‐IR), and vibrating‐sample magnetometer (VSM). Also the effect of many parameters on the Fe3O4 nanoparticles was studied, such as reaction temperature, pH of the solution, stirring rate and concentration of sodium oleate. And the 5‐dimethylthiazol‐2‐yl‐2,5‐ diphenyltetrazolium bromide (MTT) assay was performed to evaluate the biocompatibility of magnetite nanoparticles. The results showed that the Fe3O4 nanoparticles coated by sodium oleate had a better biocompatibility, better magnetic properties, easier washing, lower cost, and better dispersion than the magnetite nanoparticles coated by PEG. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2007
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.30909