Fatal Ulcerative and Hemorrhagic Typhlocolitis in a Pregnant Heifer Associated with Natural Bovine Enterovirus Type-1 Infection

One 2-year-old, 7.5 months pregnant Aberdeen Angus out of a herd of 100 apparently healthy cows, died within 10 hours of hospitalization. At necropsy, multiple foci of mucosal hemorrhage and ulceration were observed in the spiral colon and cecum. Virus isolation from intestinal lesions yielded a cyt...

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Bibliographic Details
Published in:Veterinary pathology 2007, Vol.44 (1), p.110-115
Main Authors: Blas-Machado, U, Saliki, J.T, Boileau, M.J, Goens, S.D, Caseltine, S.L, Duffy, J.C, Welsh, R.D
Format: Article
Language:English
Subjects:
Animals
Bovine enterovirus
Cattle
Cattle Diseases - pathology
Cattle Diseases - virology
Colitis, Ulcerative - pathology
Colitis, Ulcerative - veterinary
Colitis, Ulcerative - virology
enterocolitis
Enterovirus Infections - pathology
Enterovirus Infections - veterinary
Enterovirus Infections - virology
Enterovirus, Bovine - genetics
Enterovirus, Bovine - growth & development
Enterovirus, Bovine - ultrastructure
Fatal Outcome
Female
heifers
hemorrhage
Hemorrhage - pathology
Hemorrhage - veterinary
Hemorrhage - virology
Histocytochemistry - veterinary
histopathology
intestinal mucosa
Intestine, Small - pathology
Intestine, Small - virology
lesions (animal)
Microscopy, Electron - veterinary
pathogen identification
Pregnancy
Pregnancy Complications, Infectious - pathology
Pregnancy Complications, Infectious - veterinary
Pregnancy Complications, Infectious - virology
Reverse Transcriptase Polymerase Chain Reaction - veterinary
RNA, Viral - chemistry
RNA, Viral - genetics
viral enteritis
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Summary:One 2-year-old, 7.5 months pregnant Aberdeen Angus out of a herd of 100 apparently healthy cows, died within 10 hours of hospitalization. At necropsy, multiple foci of mucosal hemorrhage and ulceration were observed in the spiral colon and cecum. Virus isolation from intestinal lesions yielded a cytopathic virus, which was revealed by electron microscopy to be an approximately 27 nm, nonenveloped virus. Further characterization by reverse transcription-polymerase chain reaction (RT-PCR), sequencing of the 5'UTR and partial VP1 coding region, and phylogenetic analysis classified the virus isolate as bovine enterovirus type 1 (BEV-1). No other significant pathogens were detected. This is the first report of BEV-1 isolated in the USA from an animal with fatal enteric disease in more than 20 years. Further investigation is required to determine the prevalence of BEV in North America and to establish the clinical relevance of this understudied virus.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.44-1-110