Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women

Common variants of TCF7L2, encoding a beta-cell-expressed transcription factor, are strongly associated with increased risk of type 2 diabetes (T2D). We examined this association using both prospective and case-control designs. A total of 2,676 healthy European white middle-aged men from the prospec...

Full description

Bibliographic Details

Published in:	Journal of molecular medicine (Berlin, Germany) Germany), 2006-12, Vol.84 (12), p.1005-1014
Main Authors:	HUMPHRIES, Steve E, GABLE, David, ELKELES, Robert, GODSLAND, Ian, MILLER, George J, TALMUD, Philippa J, COOPER, Jackie A, IRELAND, Helen, STEPHENS, Jeffrey W, HUREL, Steven J, KA WAH LI, PALMEN, Jutta, MILLER, Michelle A, CAPPUCCIO, Francesco P
Format:	Article
Language:	eng
Subjects:	African Continental Ancestry Group - genetics Alleles Asian Continental Ancestry Group - genetics Biological and medical sciences Case-Control Studies Continental Population Groups - genetics Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance European Continental Ancestry Group - genetics Female Gene Frequency General aspects Genetic Predisposition to Disease Genetic Variation Haplotypes Humans Linkage Disequilibrium Male Medical sciences Polymorphism, Single Nucleotide Prospective Studies Risk Factors TCF Transcription Factors - genetics Transcription Factor 7-Like 2 Protein United Kingdom
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!