Preventive role of genistein in an experimental non-alcoholic steatohepatitis model

Background and Aim:  The aim of the present study was to evaluate the preventive role of genistein, a phytoestrogen with a wide variety of pharmacological effects, in an experimental non‐alcoholic steatohepatitis (NASH) model. Methods:  Thirty‐six Sprague‐Dawley rats were divided into three groups....

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Published in:Journal of gastroenterology and hepatology 2007-11, Vol.22 (11), p.2009-2014
Main Authors: Yalniz, Mehmet, Bahcecioglu, Ibrahim Halil, Kuzu, Nalan, Poyrazoglu, Orhan Kursat, Bulmus, Ozgur, Celebi, Selman, Ustundag, Bilal, Ozercan, Ibrahim Hanefi, Sahin, Kazim
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Antioxidants - pharmacology
Antioxidants - therapeutic use
Aspartate Aminotransferases - blood
Biological and medical sciences
Dietary Fats
Disease Models, Animal
Fatty Liver - blood
Fatty Liver - metabolism
Fatty Liver - pathology
Fatty Liver - prevention & control
Gastroenterology. Liver. Pancreas. Abdomen
genistein
Genistein - pharmacology
Genistein - therapeutic use
Hepatitis - blood
Hepatitis - metabolism
Hepatitis - pathology
Hepatitis - prevention & control
high fat diet
isoflavones
Lipid Peroxidation - drug effects
Liver - drug effects
Liver - enzymology
Liver - metabolism
Liver - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Malondialdehyde - blood
Malondialdehyde - metabolism
Medical sciences
non-alcoholic steatohepatitis
Organ Size
Other diseases. Semiology
oxidative stress
Oxidative Stress - drug effects
Rats
Rats, Sprague-Dawley
Transforming Growth Factor beta - blood
Tumor Necrosis Factor-alpha - blood
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Summary:Background and Aim:  The aim of the present study was to evaluate the preventive role of genistein, a phytoestrogen with a wide variety of pharmacological effects, in an experimental non‐alcoholic steatohepatitis (NASH) model. Methods:  Thirty‐six Sprague‐Dawley rats were divided into three groups. Group 1 (control) received only a standard rat diet, group 2 (placebo) was given a high fat diet (HFD) plus 0.5 mL/day saline subcutaneously, and group 3 (genistein group) a HFD plus subcutaneous genistein injection at dose of 0.2 mg/kg/day for 6 weeks. All rats were killed after 6 weeks. Serum aminotransferases, tumor necrosis factor (TNF)‐α, transforming growth factor (TGF)‐β, and plasma and liver malondialdehyde (MDA) levels were measured. Additionally, steatosis, ballooning degeneration and inflammation of the liver were examined histopathologically. Results:  Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (P 
ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.2006.04681.x