Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1- c][1,4]benzodiazepine-anthraquinone conjugates

A series of pyrrolo[2,1- c][1,4]benzodiazepine-anthraquinone conjugates have been prepared and evaluated for their DNA binding ability as well as anticancer activity. Some of these molecules have shown significant anticancer activity in a number of cancer cell lines.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2007-11, Vol.15 (22), p.6868-6875
Main Authors: Kamal, Ahmed, Ramu, R., Tekumalla, Venkatesh, Khanna, G.B.Ramesh, Barkume, Madan S., Juvekar, Aarti S., Zingde, Surekha M.
Format: Article
Language:English
Subjects:
Animals
Anthraquinones
Anthraquinones - chemical synthesis
Anthraquinones - chemistry
Anthraquinones - pharmacology
Anticancer activity
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Binding Sites
Biological and medical sciences
Cattle
Cell Line, Tumor
Cell Proliferation - drug effects
DNA - chemistry
DNA - drug effects
DNA binding
Drug Screening Assays, Antitumor
General aspects
Humans
Medical sciences
Molecular Structure
Pharmacology. Drug treatments
Pyrroles - chemical synthesis
Pyrroles - chemistry
Pyrroles - pharmacology
Pyrrolobenzodiazepines
Stereoisomerism
Structure-Activity Relationship
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Description
Summary:A series of pyrrolo[2,1- c][1,4]benzodiazepine-anthraquinone conjugates have been prepared and evaluated for their DNA binding ability as well as anticancer activity. Some of these molecules have shown significant anticancer activity in a number of cancer cell lines.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2007.08.026