Cell microvesicles during experimental endotoxemia

The dynamics of microvesicle formation in arterial blood in generalized Schwartzman phenomenon was studied. Successive (with 24-h interval) intravenous injections of endotoxin to rabbits in a dose of 1 mg/kg and 3 mg/kg caused an increase in the content of microvesicles in the blood, some of them co...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2006-11, Vol.142 (5), p.573-576
Main Authors: Zubairova, L D, Zubairov, D M, Andrushko, I A, Svintenok, G Yu, Mustafin, I G
Format: Article
Language:English
Subjects:
5'-Nucleotidase - blood
Animals
Endotoxemia - pathology
Endotoxins
Lipopolysaccharides
Male
Membrane Microdomains - drug effects
Membrane Microdomains - metabolism
Rabbits
Shwartzman Phenomenon
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Summary:The dynamics of microvesicle formation in arterial blood in generalized Schwartzman phenomenon was studied. Successive (with 24-h interval) intravenous injections of endotoxin to rabbits in a dose of 1 mg/kg and 3 mg/kg caused an increase in the content of microvesicles in the blood, some of them containing ecto-5'-nucleotidase. Biphasic changes in arterial blood clotting time and erythrocyte hemolysis were observed.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0421-8