New calogenin glycosides from Hoodia gordonii

Ten new pregnane glycosides ( 1, 3– 11) were isolated from organic extracts of aerial parts of Hoodia gordonii, which is sold as an appetite suppressant herbal supplement. The aglycone was identified as calogenin, based on the spectroscopic data of products obtained upon chemical and enzymatic degra...

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Bibliographic Details
Published in:Steroids 2007-11, Vol.72 (13), p.881-891
Main Authors: Pawar, Rahul S., Shukla, Yatin J., Khan, Ikhlas A.
Format: Article
Language:English
Subjects:
Apocynaceae - chemistry
Appetite suppressant
Asclepiadaceae
Biological and medical sciences
Calogenin
Fundamental and applied biological sciences. Psychology
Glycosides - chemistry
Glycosides - isolation & purification
Hoodia gordonii
Mass Spectrometry
Molecular Structure
P57AS3
Plant Extracts - chemistry
Pregnane
Pregnanes - chemistry
Pregnanes - isolation & purification
Vertebrates: endocrinology
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Summary:Ten new pregnane glycosides ( 1, 3– 11) were isolated from organic extracts of aerial parts of Hoodia gordonii, which is sold as an appetite suppressant herbal supplement. The aglycone was identified as calogenin, based on the spectroscopic data of products obtained upon chemical and enzymatic degradation of parent glycoside. The structures of the glycosides were established by chemical degradation studies and extensive spectroscopic techniques that included one-dimensional and two-dimensional NMR.
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2007.07.010