Effect of early gestational undernutrition on angiogenic factor expression and vascularity in the bovine placentome

The effect of early gestation maternal undernutrition followed by realimentation on placentomal vascular growth and angiogenic factor expression was determined in multiparous beef cows bred to the same bull. Cows gestating only female fetuses (n = 30) were fed in equal numbers to meet the NRC requir...

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Bibliographic Details
Published in:Journal of animal science 2007-10, Vol.85 (10), p.2464-2472
Main Authors: Vonnahme, K.A, Zhu, M.J, Borowicz, P.P, Geary, T.W, Hess, B.W, Reynolds, L.P, Caton, J.S, Means, W.J, Ford, S.P
Format: Article
Language:English
Subjects:
Angiogenesis Inducing Agents - metabolism
angiogenic factors
Animal Nutritional Physiological Phenomena
Animal productions
Animal reproduction
Animals
beef cows
Biological and medical sciences
blood capillaries
blood vessels
body condition
body weight
Cattle
Cattle - physiology
cell proliferation
Diet
Factory farming
feed intake
feeding level
Female
Food Deprivation - physiology
Fundamental and applied biological sciences. Psychology
Gestational Age
growth factors
Malnutrition
Maternal Nutritional Physiological Phenomena
messenger RNA
Neovascularization, Physiologic
nutrient intake
Organ Size
placenta
Placenta - blood supply
Placental Circulation
placental growth factor
placental programming
Pregnancy
Receptor Protein-Tyrosine Kinases - metabolism
receptors
restricted feeding
temporal variation
Terrestrial animal productions
vascular endothelial growth factor
Vascular Endothelial Growth Factors - metabolism
vascularization
Vertebrates
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Summary:The effect of early gestation maternal undernutrition followed by realimentation on placentomal vascular growth and angiogenic factor expression was determined in multiparous beef cows bred to the same bull. Cows gestating only female fetuses (n = 30) were fed in equal numbers to meet the NRC requirements (control) or were fed below the NRC requirements to lose BW (nutrient restricted; NR) from d 30 to 125 of gestation. After slaughter on d 125 of gestation, 10 control and 10 NR cows were necropsied. The remaining NR cows (n = 5) were then fed to achieve a BCS equal to their control group contemporaries (n = 5) by d 220 of gestation. All cows were fed the control diet from d 220 until 250 of gestation, when the remaining control and NR cows were slaughtered and necropsied. At necropsy, placentomes were fixed via perfusion of the caruncular and cotyledonary arteries to determine capillary vascular density. Cotyledonary (fetal placental) and caruncular (maternal placental) tissues also were snap-frozen in liquid nitrogen, and mRNA concentrations of vascular endothelial growth factor and its 2 specific receptors, fms-like tyrosine kinase and kinase insert domain containing receptor, as well as placental growth factor, were determined. There was no effect of diet or day of gestation on the percentage of proliferating caruncular cells. Although diet did not impact cotyledonary cellular proliferation, there was an increase (P < 0.05) in the percentage of proliferating cells on d 250 compared with d 125 of gestation. Nutrient restriction from d 30 to 125 increased (P
ISSN:0021-8812
1525-3163
DOI:10.2527/jas.2006-805