Body composition by dilution of deuterium oxide in Mexican children with lymphoma and solid tumors

Abstract Objective Scant information exists about the changes in body composition of children during the first months of chemotherapy. These changes can be determined by using a better method than the body mass index. This study compared the changes of body composition by dilution of deuterium oxide...

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Bibliographic Details
Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2007-10, Vol.23 (10), p.739-744
Main Authors: Barbosa-Cortés, Lourdes, M.Sc, Tapia-Rojas, Marisa, B.NSc, López-Aguilar, Enrique, M.D, Mejía-Aranguré, Juan Manuel, M.D., Ph.D, Rivera-Márquez, Hugo, M.D., M.Sc
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Adrenal Cortex Hormones - adverse effects
Adrenal Cortex Hormones - therapeutic use
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Body composition
Body Composition - drug effects
Body fat
Body mass index
Bone cancer
Cancer therapies
Cardiovascular disease
Cardiovascular diseases
Chemotherapy
Child
child nutrition
children
Children & youth
corticosterone
Deuterium
Deuterium dilution
Deuterium Oxide
Dilution
Fat-free mass
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Hospitals
Humans
Indicator Dilution Techniques
Lymphoma
Lymphoma - drug therapy
Lymphomas
Male
Medical prognosis
Methods
Mexico
Mortality
neoplasms
Neoplasms - drug therapy
obesity
overweight
Patients
Pediatric oncology
Pediatrics
Solid tumors
Tumors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Abstract Objective Scant information exists about the changes in body composition of children during the first months of chemotherapy. These changes can be determined by using a better method than the body mass index. This study compared the changes of body composition by dilution of deuterium oxide in Mexican children with lymphoma and with solid tumors. Methods Seventeen patients were enrolled and classified as having lymphoma or solid tumor. Body composition was measured by a deuterium dilution technique after the first course of chemotherapy and again after 2 and 6 mo of therapy. Data were compared by means of paired t and Student’s t tests. Simple linear regression was applied to examine the relation between age and changes in fat mass (FM) and fat-free mass (FFM). Results The groups were similar at baseline. Six months after initiation of chemotherapy, weight and height had increased ( P < 0.05) in the lymphoma group, whereas only height had increased in the solid-tumor group; total body water, FM, and FFM increased in the lymphoma group ( P < 0.01) but not in the solid-tumor group. Age did not influence FM or FFM in either group. Conclusion In children with lymphoma whose treatment included corticosteroid use, increase in FM content was demonstrated during the first 6 mo of treatment. In patients with solid tumors, FM content did not change during treatment. With an increase in FM content, one should bear in mind that overweight and obesity may result in cardiovascular disease and development of breast cancer in adult life.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2007.07.001