Three-dimensional optical coherence tomography at 1050 nm versus 800 nm in retinal pathologies: enhanced performance and choroidal penetration in cataract patients

Frequency domain optical coherence tomography (FD-OCT), based on an all-reflective high-speed InGaAs spectrometer, operating in the 1050 nm wavelength region for retinal diagnostics, enables high-speed, volumetric imaging of retinal pathologies with greater penetration into choroidal tissue is compa...

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Bibliographic Details
Published in:Journal of biomedical optics 2007-07, Vol.12 (4), p.041211-041211
Main Authors: Povazay, Boris, Hermann, Boris, Unterhuber, Angelika, Hofer, Bernd, Sattmann, Harald, Zeiler, Florian, Morgan, James E, Falkner-Radler, Christiane, Glittenberg, Carl, Blinder, Susanne, Drexler, Wolfgang
Format: Article
Language:English
Subjects:
Algorithms
Bandwidth
Cataract - pathology
Cataracts
Choroid - pathology
High speed
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
Optical Coherence Tomography
Pathology
Patients
Penetration
Reproducibility of Results
Retina - pathology
Retinal Diseases - pathology
Retinoscopy - methods
Sensitivity and Specificity
Spectrophotometry, Infrared - methods
Tomography, Optical Coherence - methods
Wavelengths
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Summary:Frequency domain optical coherence tomography (FD-OCT), based on an all-reflective high-speed InGaAs spectrometer, operating in the 1050 nm wavelength region for retinal diagnostics, enables high-speed, volumetric imaging of retinal pathologies with greater penetration into choroidal tissue is compared to conventional 800 nm three-dimensional (3-D) ophthalmic FD-OCT systems. Furthermore, the lower scattering at this wavelength significantly improves imaging performance in cataract patients, thereby widening the clinical applicability of ophthalmic OCT. The clinical performance of two spectrometer-based ophthalmic 3-D OCT systems compared in respect to their clinical performance, one operating at 800 nm with 150 nm bandwidth (approximately 3 microm effective axial resolution) and the other at 1050 nm with 70 nm bandwidth (approximately 7 microm effective axial resolution). Results achieved with 3-D OCT at 1050 nm reveal, for the first time, decisive improvements in image quality for patients with retinal pathologies and clinically significant cataract.
ISSN:1083-3668
1560-2281
DOI:10.1117/1.2773728