The maintenance of individual differences in the sensitivity of acute and neuropathic pain behaviors to electroacupuncture in rats

Abstract “Responder” Sprague–Dawley (SD) rats that were sensitive to electroacupuncture (EA) in an acute thermal pain test (i.e. tail flick latency [TFL] test) maintained sensitivity to EA in the warm allodynia test after peripheral nerve injury. Similarly, the “non-responder” SD rats that were inse...

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Bibliographic Details
Published in:Brain research bulletin 2007-10, Vol.74 (5), p.357-360
Main Authors: Kim, Sun Kwang, Moon, Hak Jin, Park, Jung Hyuk, Lee, Giseog, Shin, Min-Kyu, Hong, Moo-Chang, Bae, Hyunsu, Jin, Young-Ho, Min, Byung-Il
Format: Article
Language:English
Subjects:
Acupuncture
Animals
Behavior, Animal
CCK-A receptor
Disease Models, Animal
Electroacupuncture - methods
Individuality
Long-Evans Tokushima Otsuka rats
Male
Neurology
Otsuka Long-Evans Tokushima Fatty rats
Pain - etiology
Pain Management
Pain Measurement
Peripheral Nervous System Diseases - complications
Rats
Rats, Inbred OLETF
Rats, Long-Evans
Rats, Sprague-Dawley
Reaction Time - physiology
Receptor, Cholecystokinin A - deficiency
Responder and non-responder
Sprague–Dawley rats
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Summary:Abstract “Responder” Sprague–Dawley (SD) rats that were sensitive to electroacupuncture (EA) in an acute thermal pain test (i.e. tail flick latency [TFL] test) maintained sensitivity to EA in the warm allodynia test after peripheral nerve injury. Similarly, the “non-responder” SD rats that were insensitive to EA in the TFL test were also insensitive to EA in the allodynia test. The EA-induced analgesic effects in the TFL test were significantly higher in CCK-A receptor deficient, Otsuka Long-Evans Tokushima Fatty (OLETF) rats than in their littermates, Long-Evans Tokushima Otsuka (LETO) rats. Similarly, the anti-allodynic effects of EA were significantly greater in OLETF rats than in LETO rats. These results suggest that the individual differences in the sensitivity of acute pain behavior to EA were maintained in neuropathic pain behavior following peripheral nerve injury, and that CCK-A receptor expression plays an important role in mediating this phenomenon.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2007.07.006