Sertraline, a selective serotonin reuptake inhibitor, affects thirst, salt appetite and plasma levels of oxytocin and vasopressin in rats

We investigated the effects of chronic administration of sertraline (SERT; ∼20 mg kg −1 day −1 in drinking water), a selective serotonin reuptake inhibitor, on water and sodium intake and on plasma levels of oxytocin (OT) and vasopressin (AVP) in basal and stimulated conditions. Basal water in...

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Published in:Experimental physiology 2007-09, Vol.92 (5), p.913-922
Main Authors: Ana Paula de Magalhães-Nunes, Daniel Badauê-Passos, Jr, Renato Rizo Ventura, Daniel da Silva Guedes, Jr, Jacqueline Pereira Araújo, Priscila Camargo Granadeiro, Hevellyn Katarine Milanez-Barbosa, Ricardo Henrique da Costa-e-Sousa, Magda Alves de Medeiros, José Antunes-Rodrigues, Luís Carlos Reis
Format: Article
Language:English
Subjects:
Adrenergic beta-Agonists - pharmacology
Animals
Appetite - drug effects
Drinking - drug effects
Food Deprivation
Isoproterenol - pharmacology
Male
Osmotic Pressure
Oxytocin - blood
Rats
Rats, Wistar
Serotonin Uptake Inhibitors - pharmacology
Sertraline - pharmacology
Sodium Chloride, Dietary - blood
Sodium Chloride, Dietary - pharmacology
Thirst - drug effects
Urine
Vasopressins - blood
Water Deprivation
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Summary:We investigated the effects of chronic administration of sertraline (SERT; ∼20 mg kg −1 day −1 in drinking water), a selective serotonin reuptake inhibitor, on water and sodium intake and on plasma levels of oxytocin (OT) and vasopressin (AVP) in basal and stimulated conditions. Basal water intake was reduced in SERT-treated rats. After 24 h of water deprivation, rats treated with SERT for 21 days ingested less water than the control rats (9.7 ± 0.5 versus 20.0 ± 0.9 ml, respectively, at 300 min after water presentation, P < 0.0001). Subcutaneous injection of 2 m NaCl or isoproterenol evoked a lower dipsogenic response in rats treated with SERT for 21 days. Fluid and food deprivation also induced a weaker dipsogenic response in SERT-treated rats (1.6 ± 0.5 versus 10.2 ± 1.2 ml, at 300 min, P < 0.0001) but had no effect on saline intake. Sodium depletion induced a higher natriorexigenic response in the SERT group (5.6 ± 1.3 versus 1.2 ± 0.3 ml, at 300 min, P < 0.0002). Higher urinary density and lower plasma sodium levels were observed after SERT treatment. Sertraline also increased plasma levels of vasopressin and oxytocin (AVP, 2.65 ± 0.36 versus 1.31 ± 0.16 pg ml −1 , P < 0.005; OT, 17.16 ± 1.06 versus 11.3 ± 1.03 pg ml −1 , P < 0.0009, at the third week post-treatment). These data constitute the first evidence that chronic SERT treatment affects water and sodium intake in rats. These effects seem to be related to the hyponatraemia caused by the higher plasma levels of AVP and OT.
ISSN:0958-0670
1469-445X
DOI:10.1113/expphysiol.2007.037358