Brief Report: S6 Ribosomal Protein Phosphorylation in Autistic Frontal Cortex and Cerebellum: A Tissue Array Analysis

Few autistic brain samples are available for study, limiting investigations into molecular and histopathological abnormalities associated with this common disease. To facilitate distribution of samples, we have constructed a tissue array containing cerebral and cerebellar cores from 5 autistic child...

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Bibliographic Details
Published in:Journal of autism and developmental disorders 2006-11, Vol.36 (8), p.1131-1135
Main Authors: Eberhart, Charles G, Copeland, Joshua, Abel, Ty W
Format: Article
Language:English
Subjects:
Anatomy
Autism
Autistic Disorder - genetics
Autistic Disorder - metabolism
Autistic Disorder - pathology
Biological and medical sciences
Brain
Cerebellum - metabolism
Cerebellum - pathology
Child clinical studies
Comparative Analysis
Death
Dermatology
Developmental disorders
Disabilities
Diseases
Frontal Lobe - metabolism
Frontal Lobe - pathology
Genes
Genetics
Hamartoma Syndrome, Multiple - metabolism
Hamartoma Syndrome, Multiple - pathology
Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue
Heredity
Humans
Immunohistochemistry
Infantile autism
Interpersonal Relationship
Investigations
Literature Reviews
Medical Research
Medical sciences
Molecular Structure
Mutation
Nervous system
Neurology
Organic Chemistry
Patients
Phosphorylation
Proteins
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Ribosomal Protein S6 - metabolism
Signal Transduction - physiology
Tissue Array Analysis - methods
Tuberous sclerosis
Tuberous Sclerosis - metabolism
Tuberous Sclerosis - pathology
Tumors of the nervous system. Phacomatoses
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Description
Summary:Few autistic brain samples are available for study, limiting investigations into molecular and histopathological abnormalities associated with this common disease. To facilitate distribution of samples, we have constructed a tissue array containing cerebral and cerebellar cores from 5 autistic children, 1 girl with Rett syndrome, and 5 age-matched controls. To demonstrate the utility of this resource, we examined phosphorylation of the S6 ribosomal protein, a signaling event regulated by the genes mutated in tuberous sclerosis and Cowden disease. We hypothesized that the molecular pathways altered in these inherited conditions associated with autism might be dysregulated in sporadic autistic cases as well. However, no consistent alterations in S6 phosphorylation were detected in autistic tissues compared to controls in the brain regions analyzed.
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-006-0135-9