Correlation between gastrointestinal symptoms and gastric leptin and ghrelin expression in patients with gastritis

The purpose of this study was to examine the changes in gastric ghrelin and leptin with respect to Helicobacter pylori infection and whether such changes affect the plasma levels of leptin and ghrelin. In addition, we examined the relationship between changes in gastric mucosal ghrelin and leptin le...

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Bibliographic Details
Published in:Digestive diseases and sciences 2007-10, Vol.52 (10), p.2866-2872
Main Authors: Jun, Dae Won, Lee, Oh Young, Lee, Young Yul, Choi, Ho Soon, Kim, Tae Hwa, Yoon, Byung Chul
Format: Article
Language:English
Subjects:
Adult
Aged
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Biomarkers - metabolism
Biopsy
Diagnosis, Differential
Female
Gastric Mucosa - metabolism
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Gastritis - etiology
Gastritis - metabolism
Gastritis - pathology
Gastroscopy
Gene Expression
Ghrelin
Growth Hormone
Helicobacter Infections - complications
Helicobacter Infections - metabolism
Helicobacter Infections - pathology
Helicobacter pylori
Helicobacter pylori - isolation & purification
Human bacterial diseases
Humans
Infectious diseases
Leptin - biosynthesis
Leptin - genetics
Male
Medical sciences
Middle Aged
Peptide Hormones - biosynthesis
Peptide Hormones - genetics
Polymerase Chain Reaction
Prognosis
Radioimmunoassay
RNA, Messenger - genetics
Severity of Illness Index
Surveys and Questionnaires
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Summary:The purpose of this study was to examine the changes in gastric ghrelin and leptin with respect to Helicobacter pylori infection and whether such changes affect the plasma levels of leptin and ghrelin. In addition, we examined the relationship between changes in gastric mucosal ghrelin and leptin levels and gastrointestinal symptoms. Sixty-three patients diagnosed with chronic gastritis were enrolled in the study. Twenty-nine patients were Helicobacter pylori negative and 34 were Helicobacter pylori positive. Expression of ghrelin and leptin mRNA in the gastric mucosa was measured using endoscopic biopsies from the fundus. Plasma levels of ghrelin and leptin were measured by radioimmunoassay. Expression of leptin mRNA in the gastric mucosa was significantly higher in Helicobacter pylori-positive patients than in negative patients (0.38 +/- 0.17 vs. 0.24 +/- 0.12, p = 0.039). The expression of ghrelin was lower in positive patients than in the negative group, although this difference was not significant (p = 0.07). However, there was no significant difference in plasma leptin and ghrelin levels. Gastric mucosal ghrelin mRNA expression was significantly lower in patients with dyspepsia than in those without (0.15 +/- 0.11 vs. 0.23 +/- 0.20, p = 0.05). Helicobacter pylori infection and gastrointestinal symptoms could be associated with leptin and ghrelin expression in the gastric mucosa.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-006-9651-x