Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock

The segmental pattern of the spine is established early in development, when the vertebral precursors, the somites, are rhythmically produced from the presomitic mesoderm. Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscillator associated with this process, the s...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2006-12, Vol.314 (5805), p.1595-1598
Main Authors: Dequéant, Mary-Lee, Glynn, Earl, Gaudenz, Karin, Wahl, Matthias, Chen, Jie, Mushegian, Arcady, Pourquié, Olivier
Format: Article
Language:English
Subjects:
Algorithms
Animals
Biological and medical sciences
Biological clocks
Body Patterning
Embryology: invertebrates and vertebrates. Teratology
Embryonic Development - genetics
Embryos
Fibroblast Growth Factors - metabolism
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Developmental
Genes
Glycosyltransferases - genetics
Hybrid Cells
In situ hybridization
MAP Kinase Signaling System
Medical research
Mesoderm
Mesoderm - metabolism
Messenger RNA
Mice
Molecular embryology
Multigene Family
Oligonucleotide Array Sequence Analysis
Oscillation
Oscillators
Prenatal development
Receptors, Notch - metabolism
Rodents
Signal transduction
Signal Transduction - genetics
Somites - cytology
Somites - metabolism
Time series
Transcription factors
Transcription, Genetic
Wnt Proteins - metabolism
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Summary:The segmental pattern of the spine is established early in development, when the vertebral precursors, the somites, are rhythmically produced from the presomitic mesoderm. Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscillator associated with this process, the segmentation clock, drives the periodic expression of a large network of cyclic genes involved in cell signaling. Mutually exclusive activation of the notch-fibroblast growth factor and Wnt pathways during each cycle suggests that coordinated regulation of these three pathways underlies the clock oscillator.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1133141