Pulmonary pleomorphic carcinoma producing hCG

An 80‐year‐old woman with a pleomorphic carcinoma (PC) producing hCG was admitted to Nippon Steel Hirohata Hospital because of an abnormal shadow on CT seen during a follow‐up examination after surgery for breast cancer. A right upper lobectomy was performed due to rapid growth of the shadow 3 month...

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Bibliographic Details
Published in:Pathology international 2007-10, Vol.57 (10), p.698-702
Main Authors: Hirano, Hiroshi, Yoshida, Toshimi, Sakamoto, Toshihito, Yoshimura, Hitoshi, Fukuoka, Masato, Tachibana, Shiro, Saito, Hiroshi, Ohkubo, Eriko, Nakasho, Keiji, Nishigami, Takashi
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - secondary
Adenocarcinoma - therapy
Aged, 80 and over
Biomarkers, Tumor - metabolism
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - secondary
Carcinosarcoma - metabolism
Carcinosarcoma - secondary
Carcinosarcoma - therapy
Chorionic Gonadotropin - metabolism
Combined Modality Therapy
Fatal Outcome
Female
human chorionic gonadotropin (hCG)
Humans
immunohistochemistry
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Lung Neoplasms - therapy
pleomorphic carcinoma
Radiography, Thoracic
Tomography, X-Ray Computed
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Summary:An 80‐year‐old woman with a pleomorphic carcinoma (PC) producing hCG was admitted to Nippon Steel Hirohata Hospital because of an abnormal shadow on CT seen during a follow‐up examination after surgery for breast cancer. A right upper lobectomy was performed due to rapid growth of the shadow 3 months later. Macroscopically the tumor was a 4.8 × 4.0 cm well‐circumscribed grayish‐white mass. On histology the tumor consisted mostly of intermingled spindle and polygonal cells, while evidence of poorly differentiated adenocarcinoma was seen in a few areas. A diagnosis of PC was made due to hCG expression in approximately 20% of the spindle and polygonal cells on immunohistology. Six months after the operation metastasis to the liver and adrenal gland was seen on CT. The patient died due to metastases 1 year after the operation, even though the patient had been at stage 1B at the time of the operation and appropriate chemotherapy had been given. PC patients with immunohistochemical hCG expression have elevated risk of local recurrence and metastasis.
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.2007.02160.x