Emergence of serine carbapenemases (KPC and SME) among clinical strains of Enterobacteriaceae isolated in the United States Medical Centers: Report from the MYSTIC Program (1999–2005)

Among 8885 Enterobacteriaceae tested in the 1999 to 2005 period as part of the USA Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) Program, 51 strains with increased imipenem and meropenem MIC values (≥2 μg/mL) were detected. bla KPC was identified from 28 Klebsiella pneumoniae...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2006-12, Vol.56 (4), p.367-372
Main Authors: Deshpande, Lalitagauri M., Rhomberg, Paul R., Sader, Helio S., Jones, Ronald N.
Format: Article
Language:English
Subjects:
Academic Medical Centers
Anti-Bacterial Agents - pharmacology
Bacterial Proteins - biosynthesis
Bacterial Proteins - chemistry
Bacteriology
beta-Lactamases - biosynthesis
beta-Lactamases - chemistry
Biological and medical sciences
Citrobacter freundii
Enterobacter
Enterobacteriaceae
Enterobacteriaceae - drug effects
Enterobacteriaceae - enzymology
Enterobacteriaceae - isolation & purification
Enterobacteriaceae Infections - microbiology
Escherichia coli
Fundamental and applied biological sciences. Psychology
Humans
Imipenem - pharmacology
Infectious diseases
Klebsiella oxytoca
Klebsiella pneumoniae
KPC
Medical sciences
Microbial Sensitivity Tests
Microbiology
Miscellaneous
MYSTIC Program
New York
Population Surveillance
Serine
Serratia marcescens
SME
Species Specificity
Thienamycins - pharmacology
United States
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Summary:Among 8885 Enterobacteriaceae tested in the 1999 to 2005 period as part of the USA Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) Program, 51 strains with increased imipenem and meropenem MIC values (≥2 μg/mL) were detected. bla KPC was identified from 28 Klebsiella pneumoniae from 3 medical centers in the New York City area (8 ribotypes), 2 Klebsiella oxytoca from Arkansas (same ribotype), 7 Citrobacter freundii (6 from New York [5 ribotypes] and 1 from Delaware), 4 Enterobacter spp. from New York (2 species, different ribotypes), 3 Escherichia coli (2 from New York and 1 from Ohio, same ribotype), and 1 Serratia marcescens (New York). Sequencing confirmed KPC-2 or -3 in all of the strains. S. marcescens strains harboring SME-1 (2 isolates, same ribotype) and SME-2 (1 isolate) were identified from medical centers in Illinois and Washington state, respectively. Our results indicate that bla KPC-2/3 has emerged widely (New York City area, Arkansas, Delaware, and Ohio) among Enterobacteriaceae isolated in the MYSTIC Program participant sites (2000–2005) and continues to be isolated from multiple species, as a result of clonal expansion and horizontal gene transfer. The escalating occurrence (0.35%) of serine carbapenemases could compromise the role of carbapenems and other β-lactams in USA clinical practice although observed in only a few locations to date.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2006.07.004