Involvement of the Myelin-Associated Inhibitor Nogo-A in Early Cortical Development and Neuronal Maturation

Nogo-A is a myelin-associated protein expressed by neurons and myelinating mature oligodendrocytes in the central nervous system. Although most research has focused on the participation of Nogo-A in the prevention of axonal regeneration and plasticity in the adult, little attention has been paid to...

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Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2007-10, Vol.17 (10), p.2375-2386
Main Authors: Mingorance-Le Meur, Ana, Zheng, Binhai, Soriano, Eduardo, del Río, José A.
Format: Article
Language:English
Subjects:
Aging
Animals
axon tract
Axons - physiology
Brain Mapping
Cell Movement
Cerebral Cortex - embryology
Cerebral Cortex - growth & development
Cerebral Cortex - physiology
Cytoskeleton - physiology
Fetus
Gene Expression Regulation, Developmental
Immunohistochemistry
In Situ Hybridization
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Myelin Proteins - deficiency
Myelin Proteins - genetics
Myelin Proteins - physiology
Nerve Regeneration - physiology
Neurites - ultrastructure
Neurons - physiology
Nogo
Nogo Proteins
radial glia
tangential migration
Telencephalon - embryology
Telencephalon - enzymology
Telencephalon - physiology
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Summary:Nogo-A is a myelin-associated protein expressed by neurons and myelinating mature oligodendrocytes in the central nervous system. Although most research has focused on the participation of Nogo-A in the prevention of axonal regeneration and plasticity in the adult, little attention has been paid to the putative functions of Nogo-A during embryonic development. Here we examined the general pattern and cell-specific distribution of Nogo-A in the prenatal mouse telencephalon. In addition, we studied the development of the major axon tracts and radial and tangential migration in Nogo-A/B/C knockout mice. The pattern of Nogo-A showed distinct distribution in radial glia and postmitotic neurons, in which it is particularly enriched in developing axons. Similarly, Nogo-A was enriched at the leading process of tangentially migrating interneurons but not detectable in radial migrating neurons. Although a low level of Nogo-A appears to be on the surface of many cortical neurons, most proteins have intracellular localization. In Nogo-deficient background, neurons displayed early polarization and increased branching in vitro, probably reflecting a cell-intrinsic role of Nogo proteins in branching reduction, and early tangential migration was delayed. On the basis of these observations, we propose that Nogo proteins, particularly Nogo-A, are involved in multiple processes during cortical development.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhl146