Serial Changes in von Willebrand Factor-Cleaving Protease (ADAMTS13) and Prognosis After Acute Myocardial Infarction

Von Willebrand factor (VWF), a cofactor in platelet adhesion and aggregation, increases hemostasis and thrombosis. Recently, a metalloprotease that cleaves VWF multimers has been identified, namely ADAMTS13. The aim of this study was to investigate the relation between serial changes in plasma VWF a...

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Bibliographic Details
Published in:The American journal of cardiology 2007-09, Vol.100 (5), p.758-763
Main Authors: Matsukawa, Masakazu, MD, Kaikita, Koichi, MD, Soejima, Kenji, PhD, Fuchigami, Shunichiro, MD, Nakamura, Yoshinori, MD, Honda, Tsuyoshi, MD, Tsujita, Kenichi, MD, Nagayoshi, Yasuhiro, MD, Kojima, Sunao, MD, Shimomura, Hideki, MD, Sugiyama, Seigo, MD, Fujimoto, Kazuteru, MD, Yoshimura, Michihiro, MD, Nakagaki, Tomohiro, PhD, Ogawa, Hisao, MD
Format: Article
Language:English
Subjects:
ADAM Proteins - blood
ADAMTS13 Protein
Adult
Aged
Aged, 80 and over
Angina, Unstable - etiology
Anticoagulants - therapeutic use
Antigens
Aspirin - therapeutic use
Biological and medical sciences
Cardiac Output, Low - etiology
Cardiology. Vascular system
Cardiovascular
Case-Control Studies
Coronary heart disease
Female
Follow-Up Studies
Forecasting
Heart
Heart attacks
Heparin - therapeutic use
Humans
Male
Medical prognosis
Medical sciences
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - drug therapy
Myocarditis. Cardiomyopathies
Patient Admission
Patient Readmission
Platelet Aggregation Inhibitors - therapeutic use
Prognosis
Proteases
Studies
Thrombosis - etiology
von Willebrand Factor - analysis
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Description
Summary:Von Willebrand factor (VWF), a cofactor in platelet adhesion and aggregation, increases hemostasis and thrombosis. Recently, a metalloprotease that cleaves VWF multimers has been identified, namely ADAMTS13. The aim of this study was to investigate the relation between serial changes in plasma VWF and ADAMTS13 and the prognosis after acute myocardial infarction (AMI). We measured serial changes of plasma VWF and ADAMTS13 antigen levels in 92 patients with AMI and 40 control subjects. VWF levels were significantly higher in patients with AMI compared with controls (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2007.03.095