Resting Heart Rate in Cardiovascular Disease

Resting Heart Rate in Cardiovascular Disease Kim Fox, Jeffrey S. Borer, A. John Camm, Nicolas Danchin, Roberto Ferrari, Jose L. Lopez Sendon, Philippe Gabriel Steg, Jean-Claude Tardif, Luigi Tavazzi, Michal Tendera, for the Heart Rate Working Group Recent large epidemiologic studies have confirmed e...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2007-08, Vol.50 (9), p.823-830
Main Authors: Fox, Kim, MD, FESC, Borer, Jeffrey S., MD, FACC, Camm, A. John, MD, FESC, FACC, Danchin, Nicolas, MD, FESC, Ferrari, Roberto, MD, FESC, Lopez Sendon, Jose L., MD, FESC, FACC, Steg, Philippe Gabriel, MD, FESC, FACC, Tardif, Jean-Claude, MD, FACC, FRCPC, Tavazzi, Luigi, MD, FESC, FACC, Tendera, Michal, MD, FESC, FACC
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - pharmacology
Animals
Arrhythmias, Cardiac - drug therapy
Arrhythmias, Cardiac - physiopathology
Biological and medical sciences
Calcium Channel Blockers - pharmacology
Carbazoles - therapeutic use
Cardiac Output, Low - mortality
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - mortality
Cardiovascular Diseases - physiopathology
Coronary Artery Disease - drug therapy
Coronary Artery Disease - physiopathology
Coronary Disease - mortality
Coronary Disease - physiopathology
Coronary vessels
Exercise Test
Heart attacks
Heart Rate - drug effects
Heart Rate - physiology
Humans
Internal Medicine
Medical sciences
Metoprolol - therapeutic use
Mortality
Multivariate Analysis
Myocardial Infarction - mortality
Myocardial Ischemia - physiopathology
Older people
Prognosis
Propanolamines - therapeutic use
Risk Assessment
Risk Factors
Timolol - therapeutic use
Ventricular Dysfunction, Left - physiopathology
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Summary:Resting Heart Rate in Cardiovascular Disease Kim Fox, Jeffrey S. Borer, A. John Camm, Nicolas Danchin, Roberto Ferrari, Jose L. Lopez Sendon, Philippe Gabriel Steg, Jean-Claude Tardif, Luigi Tavazzi, Michal Tendera, for the Heart Rate Working Group Recent large epidemiologic studies have confirmed earlier studies that showed resting heart rate (HR) to be an independent predictor of cardiovascular and all-cause mortality in men and women with and without cardiovascular disease. Clinical trial data suggest that HR reduction is an important mechanism of benefit of beta-blockers and other HR lowering drugs. Pathophysiological studies indicate that a relatively high HR has direct detrimental effects on the progression of coronary atherosclerosis, on the occurrence of myocardial ischemia and ventricular arrhythmias, and on left ventricular function. Studies have found a continuous increase in risk with HR above 60 beats/min.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.04.079