Lipoprotein lipase gene S447X polymorphism modulates the relation between central obesity and serum lipids, a twin study

Objective: To investigate the impact of lipoprotein lipase (LPL) gene S447X polymorphism on the relation between central obesity and lipid levels. Design: A total of 961 adult twin pairs were included from the program of Chinese Twin Registry, between 2001 and 2002. Central obesity was defined as wa...

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Bibliographic Details
Published in:International Journal of Obesity 2006-12, Vol.30 (12), p.1693-1701
Main Authors: Huang, A.Q, Hu, Y.H, Zhan, S.Y, Xu, B, Pang, Z.C, Cao, W.H, Lu, J, Qin, Y, Lee, L.M
Format: Article
Language:English
Subjects:
Adult
adults
alleles
Biological and medical sciences
Blood Glucose - metabolism
blood lipids
Body fat
Body Mass Index
Case-Control Studies
Cholesterol
Disease
Diseases in Twins - blood
Diseases in Twins - genetics
Epidemiology
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
General aspects
Genes
Genetic aspects
genetic polymorphism
Genetic polymorphisms
Genotype
High density lipoprotein
Humans
Lipids
Lipids - blood
Lipoprotein lipase
Lipoprotein Lipase - genetics
Lipoproteins
Male
mathematical models
Medical sciences
men
Metabolic diseases
Middle Aged
Obesity
Obesity - blood
Obesity - genetics
Polymorphism
Polymorphism, Genetic
Population
Public health
Risk factors
triacylglycerols
Twin studies
Twins
Vertebrates: anatomy and physiology, studies on body, several organs or systems
waist circumference
Weight control
women
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Summary:Objective: To investigate the impact of lipoprotein lipase (LPL) gene S447X polymorphism on the relation between central obesity and lipid levels. Design: A total of 961 adult twin pairs were included from the program of Chinese Twin Registry, between 2001 and 2002. Central obesity was defined as waist circumference >or= 90 cm for male and >or= 80 cm for female. Two statistical methods were performed to test the modification effect of S447X polymorphism of LPL gene on the relation between central obesity and lipid levels: one was Generalized Estimating Equation (GEE) models for all twin pairs and the other was co-twin matched case-control analysis in 82 central obesity discordant monozygotic twin pairs. Results: In GEE models for all twins, central obesity was significantly associated with serum lipids except for high-density lipoprotein (HDL), while X447 allele had favorable effects on the levels of triglyceride (TG), HDL and TG to HDL ratio (TG/HDL). The interactions of S447X polymorphism and central obesity were statistically significant for TG/HDL and HDL. In central obesity discordant monozygotic twin pairs, central obesity was significantly related with 26.2% increase of TG and 27.2% increase of TG/HDL in S/S447 genotype, while in 447X allele carrier, central obesity was significantly related with 13.7% increase of HDL. Conclusion: These results suggest that LPL gene S447X polymorphism modifies the relation between central obesity and serum lipids, which also stresses the importance of reducing waist circumference to improve serum lipids for people with central obesity, especially those with S/S447 genotype.
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0803332