High preoperative prevalence of deep venous thrombosis in patients with colorectal cancer

Background: Deep venous thrombosis (DVT) is a major complication of cancer and a predictor of reduced survival. The postoperative prevalence of DVT in colorectal cancer surgery is high, but the preoperative prevalence is unknown. The aim of this observational study was to estimate the preoperative p...

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Bibliographic Details
Published in:British journal of surgery 2007-09, Vol.94 (9), p.1100-1103
Main Authors: Stender, M. T., Nielsen, T. S. H., Frøkjær, J. B., Larsen, T. B., Lundbye-Christensen, S., Thorlacius-Ussing, O.
Format: Article
Language:English
Subjects:
Age Factors
Anticoagulants - therapeutic use
Biological and medical sciences
Colorectal Neoplasms - complications
Colorectal Neoplasms - surgery
Epidemiology
Female
General aspects
Heparin, Low-Molecular-Weight - therapeutic use
Humans
Male
Medical sciences
Preoperative Care
Prevalence
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
Pulmonary Embolism - complications
Pulmonary Embolism - diagnostic imaging
Pulmonary Embolism - drug therapy
Risk Factors
Sex Factors
Ultrasonography
Venous Thrombosis - diagnostic imaging
Venous Thrombosis - drug therapy
Venous Thrombosis - epidemiology
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Summary:Background: Deep venous thrombosis (DVT) is a major complication of cancer and a predictor of reduced survival. The postoperative prevalence of DVT in colorectal cancer surgery is high, but the preoperative prevalence is unknown. The aim of this observational study was to estimate the preoperative prevalence of DVT in patients with colorectal cancer. Methods: Some 193 consecutive patients with newly diagnosed colorectal cancer admitted for intended curative surgery were examined with compression ultrasonography for DVT before surgery. Results: DVT was detected in 15 (7·8 per cent) of the 193 patients, with a prevalence of 16 per cent in women (12 of 76) versus 2·6 per cent in men (three of 117 (adjusted odds ratio (OR) 5·8 (95 per cent confidence interval (c.i.) 1·4 to 23·2)). The risk of DVT was strongly correlated with increasing American Society of Anesthesiologists (ASA) risk score: adjusted OR 6·8 (95 per cent c.i. 1·6 to 28·7 for ASA group III or IV versus ASA group I or II). Pulmonary embolism was detected in two patients (1·0 per cent). Conclusion: A high preoperative prevalence of DVT was observed in patients with colorectal cancer, especially among women and patients in ASA groups III and IV. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Worrying data
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.5754