The role of islet neogenesis-associated protein (INGAP) in islet neogenesis

Islet Neogenesis-Associated Protein (INGAP) is a member of the Reg family of proteins implicated in various settings of endogenous pancreatic regeneration. The expression of INGAP and other RegIII proteins has also been linked temporally and spatially with the induction of islet neogenesis in animal...

Full description

Saved in:
Bibliographic Details
Published in:Cell biochemistry and biophysics 2007-01, Vol.48 (2-3), p.127-137
Main Authors: Lipsett, Mark, Hanley, Stephen, Castellarin, Mauro, Austin, Emily, Suarez-Pinzon, Wilma L, Rabinovitch, Alex, Rosenberg, Lawrence
Format: Article
Language:English
Subjects:
Animals
Antigens, Neoplasm - pharmacology
Antigens, Neoplasm - physiology
Biomarkers, Tumor - pharmacology
Biomarkers, Tumor - physiology
Clinical Trials, Phase II as Topic
Diabetes
Diabetes Mellitus - drug therapy
Diabetes Mellitus - metabolism
Drug Evaluation, Preclinical
Humans
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Islets of Langerhans - drug effects
Islets of Langerhans - metabolism
Islets of Langerhans - physiology
Lectins, C-Type - physiology
Pancreas - drug effects
Pancreas - metabolism
Pancreas - physiology
Pancreatitis-Associated Proteins
Regeneration - drug effects
Regeneration - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Islet Neogenesis-Associated Protein (INGAP) is a member of the Reg family of proteins implicated in various settings of endogenous pancreatic regeneration. The expression of INGAP and other RegIII proteins has also been linked temporally and spatially with the induction of islet neogenesis in animal models of disease and regeneration. Furthermore, administration of a peptide fragment of INGAP (INGAP peptide) has been demonstrated to reverse chemically induced diabetes as well as improve glycemic control and survival in an animal model of type 1 diabetes. Cultured human pancreatic tissue has also been shown to be responsive to INGAP peptide, producing islet-like structures with function, architecture and gene expression matching that of freshly isolated islets. Likewise, studies in normoglycemic animals show evidence of islet neogenesis. Finally, recent clinical studies suggest an effect of INGAP peptide to improve insulin production in type 1 diabetes and glycemic control in type 2 diabetes.
ISSN:1085-9195
1559-0283
DOI:10.1007/s12013-007-0028-3