Nitric Oxide Inhalation Improves Microvascular Flow and Decreases Infarction Size After Myocardial Ischemia and Reperfusion

Nitric Oxide Inhalation Improves Microvascular Flow and Decreases Infarction Size After Myocardial Ischemia and Reperfusion Xiaoshun Liu, Yanming Huang, Peter Pokreisz, Pieter Vermeersch, Glenn Marsboom, Marc Swinnen, Eric Verbeken, Jose Santos, Marijke Pellens, Hilde Gillijns, Frans Van de Werf, Ke...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2007-08, Vol.50 (8), p.808-817
Main Authors: Liu, Xiaoshun, MD, PhD, Huang, Yanming, MD, PhD, Pokreisz, Peter, PhD, Vermeersch, Pieter, MD, Marsboom, Glenn, MSc, Swinnen, Marc, Verbeken, Eric, MD, PhD, Santos, Jose, MD, Pellens, Marijke, Gillijns, Hilde, Van de Werf, Frans, MD, PhD, Bloch, Kenneth D., MD, Janssens, Stefan, MD, PhD
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Administration, Inhalation
Animals
Apoptosis
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular
Clinical trials
Coronary Circulation - drug effects
Coronary heart disease
Coronary vessels
Endothelium-Dependent Relaxing Factors - pharmacology
Endothelium-Dependent Relaxing Factors - therapeutic use
Female
Heart
Heart attacks
Heart rate
Internal Medicine
Ischemia
Male
Medical imaging
Medical sciences
Microcirculation - drug effects
Myocardial Infarction - pathology
Myocardial Ischemia - complications
Myocardial Ischemia - drug therapy
Myocardial Ischemia - physiopathology
Myocardial Reperfusion Injury - prevention & control
Myocarditis. Cardiomyopathies
Myocardium - enzymology
Myocardium - metabolism
Myocardium - pathology
Nitric Oxide - metabolism
Nitric Oxide - pharmacology
Nitric Oxide - therapeutic use
Oxidation-Reduction
Peroxidase - blood
Peroxidase - metabolism
Rodents
Software
Studies
Swine
Veins & arteries
Ventilation
Ventricular Function, Left - drug effects
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Summary:Nitric Oxide Inhalation Improves Microvascular Flow and Decreases Infarction Size After Myocardial Ischemia and Reperfusion Xiaoshun Liu, Yanming Huang, Peter Pokreisz, Pieter Vermeersch, Glenn Marsboom, Marc Swinnen, Eric Verbeken, Jose Santos, Marijke Pellens, Hilde Gillijns, Frans Van de Werf, Kenneth D. Bloch, Stefan Janssens This study tested whether or not inhaled nitric oxide (iNO) could improve microvascular perfusion and decrease tissue injury in a porcine model if myocardial ischemia and reperfusion. Pigs were treated with a saline infusion (n = 14), intravenous nitroglycerin at 2 μg/kg/min (n = 11), or iNO at 80 parts per million (n = 12), beginning 10 min before the end of a 50-min LAD balloon occlusion period and continuing throughout a 4-h reperfusion period. Inhalation of NO significantly improves microvascular perfusion, decreases leukocyte activation and cardiomyocyte apoptosis, and reduces infarct size, and may offer an attractive and novel treatment of myocardial infarction.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.04.069