Haptoglobin polymorphism and diabetic retinopathy in Brazilian patients

Abstract Haptoglobin (Hp) is an acute phase protein with antioxidant and immunomodulatory properties. Three main genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2) show distinct efficiencies in these activities and have been associated with susceptibility and outcome in several diseases, including diabet...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2007-09, Vol.77 (3), p.385-388
Main Authors: Wobeto, Vânia P.A, Rosim, Endrigo T, Melo, Mônica B, Calliari, Luís Eduardo P, Sonati, Maria de Fátima
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Brazil - epidemiology
Brazilian population
Case-Control Studies
Diabetes Mellitus
Diabetic retinopathy
Diabetic Retinopathy - epidemiology
Diabetic Retinopathy - etiology
Diabetic Retinopathy - genetics
Endocrinology & Metabolism
Gene Frequency
Genetic polymorphisms
Genotype
Haptoglobin genotypes
Haptoglobins - genetics
Humans
Middle Aged
Polymorphism, Genetic - physiology
Risk Factors
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Summary:Abstract Haptoglobin (Hp) is an acute phase protein with antioxidant and immunomodulatory properties. Three main genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2) show distinct efficiencies in these activities and have been associated with susceptibility and outcome in several diseases, including diabetes mellitus (DM). It has been suggested that Hp polymorphism may influence the development of retinopathy, an important microvascular complication in DM. In order to investigate this association in a Brazilian population, we determined the Hp genotypes of 317 diabetic patients with at least 10 years of disease. The patients were classified as DM-type 1 and 2, with and without diabetic retinopathy (DR). The Hp genotype frequencies of the different patient groups and of a control group consisting of 142 healthy individuals who had previously been studied were compared. No significant differences were observed for the three Hp genotypes. Hemoglobin A1c levels, systolic blood pressure (SBP), diastolic blood pressure (DBP) and duration of diabetes, which are potential risk factors for DR, were also compared. Again no significant differences were observed for the three Hp genotypes. Thus, we conclude that this polymorphism is not associated with the presence of DR in the Brazilian population studied here.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2006.12.018