Effect of monosodium glutamate on oxidative stress and apoptosis in rat thymus

It has been demonstrated that administration of high concentrations of monosodium glutamate (MSG), induce oxidative stress in different organs, but not in thymus. In the present study we examined the role of oxidative stress in MSG-induced thymocyte apoptosis. MSG was administrated intraperitoneally...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2007-09, Vol.303 (1-2), p.161-166
Main Authors: Pavlovic, Voja, Pavlovic, Dusica, Kocic, Gordana, Sokolovic, Dusan, Jevtovic-Stoimenov, Tatjana, Cekic, Snezana, Velickovic, Dragana
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - drug effects
Body weight
Catalase
Cell Proliferation - drug effects
Cells, Cultured
Dosage
Food Additives - pharmacology
Male
Malondialdehyde - metabolism
Monosodium glutamate
Organs
Oxidative stress
Oxidative Stress - drug effects
Rats
Rats, Wistar
Rodents
Sodium glutamate
Sodium Glutamate - pharmacology
Thymocytes
Thymus
Thymus (Lamiaceae)
Thymus gland
Thymus Gland - drug effects
Thymus Gland - metabolism
Xanthine oxidase
Xanthine Oxidase - metabolism
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Summary:It has been demonstrated that administration of high concentrations of monosodium glutamate (MSG), induce oxidative stress in different organs, but not in thymus. In the present study we examined the role of oxidative stress in MSG-induced thymocyte apoptosis. MSG was administrated intraperitoneally (4 mg/g of body weight) for six consecutive days. Animals were sacrificed at 1st, 7th, and 15th day after last MSG dose. MSG administration to animals significantly increased apoptotic rate of thymocytes (P < 0.01), together with significant increase of malondialdehyde (MDA) level (P < 0.001) and xanthine oxidase (XO) activity (P < 0.01), in time dependent manner. Catalase activity, during examination period, was significantly decreased (0 < 0.01). Obtained results showed that MSG treatment induced oxidative stress in thymus, which may have an important role in thymocyte apoptosis induced by MSG.
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-007-9469-7