Segmental left ventricular wall motion abnormalities are associated with lacunar ischemic stroke

The aim of this study was to determine whether segmental left ventricular wall motion abnormalities (SLVWMA) are a potential cause of ischemic stroke. Demographics, cardiovascular risk factors and echocardiographic parameters of patients with ischemic stroke (with and without SLVWMA) were collected...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2006-12, Vol.108 (8), p.744-749
Main Authors: Deleu, Dirk, Kamran, Saadat, Hamad, Ayman A., Hamdy, Samir M.K., Akhtar, Naveed
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Blood clots
Brain Infarction - diagnosis
Brain Infarction - epidemiology
Brain Infarction - etiology
Cardiovascular disease
Cross-Sectional Studies
Echocardiography
Expatriates
Female
Humans
Intracranial Embolism - diagnosis
Intracranial Embolism - epidemiology
Intracranial Embolism - etiology
Ischemic stroke
Lacunar stroke
Left ventricle
Magnetic Resonance Imaging
Male
Medical imaging
Medical sciences
Middle Aged
Mortality
Neurology
Neurosurgery
Older people
Risk factor
Risk Factors
Statistics as Topic
Stroke
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tomography, X-Ray Computed
Ventricular Dysfunction, Left - complications
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - epidemiology
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Summary:The aim of this study was to determine whether segmental left ventricular wall motion abnormalities (SLVWMA) are a potential cause of ischemic stroke. Demographics, cardiovascular risk factors and echocardiographic parameters of patients with ischemic stroke (with and without SLVWMA) were collected and compared with those of patients who had SLVWMA but without history of ischemic stroke. Two hundred and fifty nine patients with ischemic stroke were identified: 187 patients without SLVWMA, and 72 with SLVWMA. The cardiac group consisted of 79 patients. Compared with the stroke patients with SLVWMA, stroke patients without SLVWMA were slightly but significantly younger (59 versus 63 years of age). Furthermore, the number of risk factors in stroke patients without SLVWMA was significantly lower compared with stroke patients with SLVWMA (2.7 versus 3.7). There was no difference in age or gender between stroke patients with SLVWMA and the cardiac patients. However, the number of risk factors was significantly higher in the cardiac patients compared with stroke patients with SLVWMA (4.4 versus 3.7). The ejection fraction was normal in both groups of stroke patients but significantly lower in the cardiac patients (37%). Significantly more lacunar ischemic strokes were observed in stroke patients with SLVWMA than in those without SLVWMA (76% versus 68%). Our data indicate that in ischemic stroke patients with multiple cardiovascular risk factors and SLVWMA a higher frequency of lacunar strokes can be found. The latter could be a marker of small-vessel disease and/or be a potential contributing factor, perhaps through a mechanism of cardiac microembolism, in the development of lacunar ischemic stroke. The mechanisms of the association between SLVWMA and lacunar ischemic stroke remain however unclear.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2006.03.005