Box-Behnken design: An alternative for the optimization of analytical methods

The present paper describes fundamentals, advantages and limitations of the Box-Behnken design (BBD) for the optimization of analytical methods. It establishes also a comparison between this design and composite central, three-level full factorial and Doehlert designs. A detailed study on factors an...

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Bibliographic Details
Published in:Analytica chimica acta 2007-08, Vol.597 (2), p.179-186
Main Authors: Ferreira, S.L.C., Bruns, R.E., Ferreira, H.S., Matos, G.D., David, J.M., Brandão, G.C., da Silva, E.G.P., Portugal, L.A., dos Reis, P.S., Souza, A.S., dos Santos, W.N.L.
Format: Article
Language:English
Subjects:
Analytical chemistry
Analytical methods
Box-Behnken design
Chemistry
Desirability function
Exact sciences and technology
Experimental design
General, instrumentation
Multivariate optimization
Robustness
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Summary:The present paper describes fundamentals, advantages and limitations of the Box-Behnken design (BBD) for the optimization of analytical methods. It establishes also a comparison between this design and composite central, three-level full factorial and Doehlert designs. A detailed study on factors and responses involved during the optimization of analytical systems is also presented. Functions developed for calculation of multiple responses are discussed, including the desirability function , which was proposed by Derringer and Suich in 1980. Concept and evaluation of robustness of analytical methods are also discussed. Finally, descriptions of applications of this technique for optimization of analytical methods are presented.
ISSN:0003-2670
1873-4324
DOI:10.1016/j.aca.2007.07.011