Increased Akt and phosphorylated Akt expression are associated with malignant biological features of prostate cancer in Japanese men

OBJECTIVE To investigate the relationship between the expression of Akt (a serine/threonine kinase that plays a central role in tumorigenesis), phosphorylated Akt (p‐Akt), prostate cancer tumour grade, androgen receptor (AR)‐staining score, and Ki67 labelling index (LI) in Japanese men. PATIENTS, MA...

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Bibliographic Details
Published in:BJU international 2007-09, Vol.100 (3), p.685-690
Main Authors: Shimizu, Yousuke, Segawa, Takehiko, Inoue, Takahiro, Shiraishi, Taizo, Yoshida, Toru, Toda, Yoshinobu, Yamada, Tomomi, Kinukawa, Naoko, Terada, Naoki, Kobayashi, Takashi, Kinoshita, Hidefumi, Kamoto, Toshiyuki, Nakamura, Eijiro, Ogawa, Osamu
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Aged
Akt
androgen receptor
Biological and medical sciences
Biomarkers, Tumor - metabolism
Disease-Free Survival
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Japan
Ki-67 Antigen - metabolism
Male
Male genital diseases
Medical sciences
Microarray Analysis
Middle Aged
Multivariate Analysis
Nephrology. Urinary tract diseases
phosphorylated Akt
Phosphorylation
prostate cancer
Prostate-Specific Antigen - blood
Prostatectomy
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Proto-Oncogene Proteins c-akt - metabolism
Receptors, Androgen - metabolism
Tumors
Tumors of the urinary system
Urinary tract. Prostate gland
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Summary:OBJECTIVE To investigate the relationship between the expression of Akt (a serine/threonine kinase that plays a central role in tumorigenesis), phosphorylated Akt (p‐Akt), prostate cancer tumour grade, androgen receptor (AR)‐staining score, and Ki67 labelling index (LI) in Japanese men. PATIENTS, MATERIALS AND METHODS The expression and activation of the cell survival protein Akt was analysed by immunohistochemical staining of paraffin‐embedded tissue microarray sections of prostate carcinoma taken from 52 Japanese men who under radical prostatectomy. The correlation between the expression of Akt and p‐Akt, and their relationship to primary Gleason grade, AR expression and Ki‐67 LI was investigated. RESULTS The expression of Akt and p‐Akt were positively related to primary Gleason grade (Fisher’s exact test, P = 0.002 and P = 0.032, respectively). Both AR‐staining score and Ki67 LI were were positively related to the expression of Akt (both P 
ISSN:1464-4096
1464-410X
DOI:10.1111/j.1464-410X.2007.07014.x