Possible mechanisms of neurodegeneration in schizophrenia

Brain morphological alterations in schizophrenic patients have led to the neurodevelopmental hypothesis of schizophrenia. On the other hand, a progressive neurodegenerative process has also been suggested and some follow-up studies have shown progressive morphological changes in schizophrenic patien...

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Bibliographic Details
Published in:Neurochemical research 2006-10, Vol.31 (10), p.1279-1294
Main Authors: Pérez-Neri, Iván, Ramírez-Bermúdez, Jesús, Montes, Sergio, Ríos, Camilo
Format: Article
Language:English
Subjects:
Antipsychotic Agents - therapeutic use
Brain - abnormalities
Dopamine - physiology
Glutamic Acid - physiology
Humans
Neurodegenerative Diseases - drug therapy
Neurodegenerative Diseases - physiopathology
Nitric Oxide - biosynthesis
Schizophrenia - drug therapy
Schizophrenia - physiopathology
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Summary:Brain morphological alterations in schizophrenic patients have led to the neurodevelopmental hypothesis of schizophrenia. On the other hand, a progressive neurodegenerative process has also been suggested and some follow-up studies have shown progressive morphological changes in schizophrenic patients. Several neurotransmitter systems have been suggested to be involved in this disorder and some of them could lead to neuronal death under certain conditions. This review discusses some of the biochemical pathways that could lead to neurodegeneration in schizophrenia showing that neuronal death may have a role in the etiology or natural course of this disorder.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-006-9162-3